1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Opción 2: Descargar recurso

Opción 3: Descargar recurso

Detalles del recurso

Descripción

Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, we quantified the nuclear Dorsal gradient in space and time and found that its amplitude and basal levels display oscillations throughout early embryonic development. These dynamics raise questions regarding how cells can reproducibly establish patterns of gene expression from a rapidly varying signal. We therefore quantified domains of Dorsal target genes, discovering their expression patterns are also dynamic. Computational modeling of this system reveals a correlation between Dorsal gradient dynamics and changes in target gene expression and suggests that these dynamics, together with time averaging of noise, results in the formation of graded gene expression borders in regions where the gradient is nearly flat. We propose that mRNA levels remain plastic during transient signaling events, allowing tissues to refine patterns in the face of genetic or environmental variation.

Pertenece a

Caltech Authors  

Autor(es)

Reeves, Gregory T. -  Trisnadi, Nathanie -  Truong, Thai V. -  Nahmad, Marcos -  Katz, Sophie -  Stathopoulos, Angelike - 

Id.: 55201138

Versión: 1.0

Estado: Final

Tipo:  application/pdf -  application/pdf -  video/quicktime - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/pdf -  application/pdf -  video/quicktime - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147
[References] http://authors.library.caltech.edu/30082/

Fecha de contribución: 25-abr-2017

Contacto:

Localización:
* Reeves, Gregory T. and Trisnadi, Nathanie and Truong, Thai V. and Nahmad, Marcos and Katz, Sophie and Stathopoulos, Angelike (2012) Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient. Developmental Cell, 22 (3). pp. 544-557. ISSN 1534-5807. PMCID PMC3469262. http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147

Otros recursos del mismo autor(es)

  1. Broadly expressed repressors integrate patterning across orthogonal axes in embryos The role of spatially localized repressors in supporting embryonic patterning is well appreciated, b...
  2. Regulation of Gastrulation Through Dynamic Patterning in the Drosophila Embryo Gene patterning delineates an embryo into precise domains of differential gene expression. However,...
  3. Stepwise Progression of Embryonic Patterning It is long established that the graded distribution of Dorsal transcription factor influences spatia...
  4. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis The diverse morphology of vertebrate skeletal system is genetically controlled, yet the means by whi...
  5. Dynamic structure and protein expression of the live embryonic heart captured by 2-photon light sheet microscopy and retrospective registration We present an imaging and image reconstruction pipeline that captures the dynamic three-dimensional ...

Otros recursos de la mismacolección

  1. Bioinspired phase-separated disordered nanostructures for thin photovoltaic absorbers The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured...
  2. Elucidating the underlying components of food valuation in the human orbitofrontal cortex The valuation of food is a fundamental component of our decision-making. Yet little is known about h...
  3. A Statistical Graphical Model of the California Reservoir System The recent California drought has highlighted the potential vulnerability of the state's water manag...
  4. The 2016 Kumamoto M_w = 7.0 earthquake: a significant event in a fault-volcano system The 2016 Kumamoto earthquake sequence occurred on the Futagawa-Hinagu fault zone near the Aso volcan...
  5. Search for top quark partners with charge 5/3 in proton-proton collisions at √s = 13 TeV A search for the production of heavy partners of the top quark with charge 5/3 (X_(5/3)) decaying in...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.