1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Detalles del recurso


Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, we quantified the nuclear Dorsal gradient in space and time and found that its amplitude and basal levels display oscillations throughout early embryonic development. These dynamics raise questions regarding how cells can reproducibly establish patterns of gene expression from a rapidly varying signal. We therefore quantified domains of Dorsal target genes, discovering their expression patterns are also dynamic. Computational modeling of this system reveals a correlation between Dorsal gradient dynamics and changes in target gene expression and suggests that these dynamics, together with time averaging of noise, results in the formation of graded gene expression borders in regions where the gradient is nearly flat. We propose that mRNA levels remain plastic during transient signaling events, allowing tissues to refine patterns in the face of genetic or environmental variation.

Pertenece a

Caltech Authors  


Reeves, Gregory T. -  Trisnadi, Nathanie -  Truong, Thai V. -  Nahmad, Marcos -  Katz, Sophie -  Stathopoulos, Angelike - 

Id.: 55201138

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147
[References] http://authors.library.caltech.edu/30082/

Fecha de contribución: 24-ago-2016


* Reeves, Gregory T. and Trisnadi, Nathanie and Truong, Thai V. and Nahmad, Marcos and Katz, Sophie and Stathopoulos, Angelike (2012) Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient. Developmental Cell, 22 (3). pp. 544-557. ISSN 1534-5807. http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147

Otros recursos del mismo autor(es)

  1. The migrations of Drosophila muscle founders and primordial germ cells are interdependent Caudal visceral mesoderm (CVM) cells migrate from posterior to anterior of the Drosophila embryo as ...
  2. Analyzing negative feedback using a synthetic gene network expressed in the Drosophila melanogaster embryo
  3. FGF signaling supports Drosophila fertility by regulating development of ovarian muscle tissues The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are vi...
  4. Stepwise Progression of Embryonic Patterning It is long established that the graded distribution of Dorsal transcription factor influences spatia...
  5. Quantitative Single-Embryo Profile of Drosophila Genome Activation and the Dorsal-Ventral Patterning Network During embryonic development of Drosophila melanogaster, the Maternal to Zygotic Transition (MZT) ma...

Otros recursos de la misma colección

  1. Surface Photometry and the Structure of Elliptical Galaxies This paper reviews surface photometry of bulges and elliptical galaxies. Work prior to 1982 is discu...
  2. The Immutability of Categories and the Reshaping of Southern Politics How did the no-party, extremely-low-turnout, fragmented political system that V.O. Key, Jr. describe...
  3. Application of Nuclear Magnetic Resonance to Solids: High Resolution Techniques Nuclear magnetic resonance (NMR) has long been a useful technique for the study of solids (1, 2). Wi...
  4. Ion Cyclotron Resonance Spectroscopy [No abstract]
  5. Electrochemistry [No abstract]

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.