Sunday, January 25, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, we quantified the nuclear Dorsal gradient in space and time and found that its amplitude and basal levels display oscillations throughout early embryonic development. These dynamics raise questions regarding how cells can reproducibly establish patterns of gene expression from a rapidly varying signal. We therefore quantified domains of Dorsal target genes, discovering their expression patterns are also dynamic. Computational modeling of this system reveals a correlation between Dorsal gradient dynamics and changes in target gene expression and suggests that these dynamics, together with time averaging of noise, results in the formation of graded gene expression borders in regions where the gradient is nearly flat. We propose that mRNA levels remain plastic during transient signaling events, allowing tissues to refine patterns in the face of genetic or environmental variation.

Autor(es): Reeves, Gregory T. -  Trisnadi, Nathanie -  Truong, Thai V. -  Nahmad, Marcos -  Katz, Sophie -  Stathopoulos, Angelike - 

Id.: 55201138

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147
[References] http://authors.library.caltech.edu/30082/

Fecha de contribución: 14-abr-2012

Contacto:

Localización:
* Reeves, Gregory T. and Trisnadi, Nathanie and Truong, Thai V. and Nahmad, Marcos and Katz, Sophie and Stathopoulos, Angelike (2012) Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient. Developmental Cell, 22 (3). pp. 544-557. ISSN 1534-5807 http://resolver.caltech.edu/CaltechAUTHORS:20120413-134016147


Otros recursos del mismo autor(es)

  1. Ectopic Expression Screen Identifies Genes Affecting Drosophila Mesoderm Development Including the HSPG Trol Gastrulation of the embryo involves coordinate cell movements likely supported by multiple signaling...
  2. Su(H)-Mediated Repression Positions Gene Boundaries along the Dorsal-Ventral Axis of Drosophila Embryos In Drosophila embryos, a nuclear gradient of the Dorsal (Dl) transcription factor directs differenti...
  3. Studies of morphogens: keep calm and carry on Morphogens are signaling factors that direct cell fate and tissue development at a distance from the...
  4. Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV)...
  5. Image analysis and empirical modeling of gene and protein expression Protein gradients and gene expression patterns are major determinants in the differentiation and fat...

Otros recursos de la misma colección

  1. Metal contact double injection in GaAs Recent studies on the GaAs injection laser have indicated certain problems associated with the local...
  2. Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking Artificial extracellular matrix proteins, genetically engineered from elastin- and fibronectin-deriv...
  3. Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins This study examines the spreading and adhesion of human umbilical vein endothelial cells (HUVEC) on ...
  4. A Hierarchical Timing Simulation Model A hierarchical timing simulation model has been developed to deal with VLSI designs at any level of ...
  5. Immunomicrospheres: reagents for cell labeling and separation Immunomicrospheres are specially designed microscopic particles that have antibodies or similar mole...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso