Detalles del recurso

Descripción

T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and binding repertoire of GATA-3 and PU.1, transcription factors with complementary roles in T cell development. The results highlight potential promoter-distal cis-regulatory elements in play and reveal both activation sites and diverse mechanisms of repression that silence genes used in alternative lineages. Histone marking is dynamic and reversible, and though permissive marks anticipate, repressive marks often lag behind changes in transcription. In vivo binding of PU.1 and GATA-3 relative to epigenetic marking reveals distinctive factor-specific rules for recruitment of these crucial transcription factors to different subsets of their potential sites, dependent on dose and developmental context.

Pertenece a

Caltech Authors  

Autor(es)

Zhang, Jingli A. -  Mortazavi, Ali -  Williams, Brian A. -  Wold, Barbara J. -  Rothenberg, Ellen V. - 

Id.: 55304949

Versión: 1.0

Estado: Final

Tipo:  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  text/xml -  application/pdf -  application/vnd.ms-excel - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  text/xml -  application/pdf -  application/vnd.ms-excel - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604
[References] http://authors.library.caltech.edu/31437/

Fecha de contribución: 24-ago-2016

Contacto:

Localización:
* Zhang, Jingli A. and Mortazavi, Ali and Williams, Brian A. and Wold, Barbara J. and Rothenberg, Ellen V. (2012) Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity. Cell, 149 (2). pp. 467-482. ISSN 0092-8674. http://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604

Otros recursos del mismo autor(es)

  1. TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products...
  2. Proceedings of the 13th annual conference of INEBRIA
  3. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their fo...
  4. TeraScalable Algorithms for Variable-Density Elliptic Hydrodynamics with Spectral Accuracy We describe Miranda, a massively parallel spectral/compact solver for variabledensity incompressible...
  5. Memantine on the Volitional Consumption of Ethanol by Alcohol-Preferring Rats The effect of memantine in harmaline-induced tremor and neurodegeneration

Otros recursos de la mismacolección

  1. Intrinsic universality in tile self-assembly requires cooperation We prove a negative result on the power of a model of algorithmic self-assembly for which finding ge...
  2. Architecture Uniting commodity processors by the thousands, emerging parallel architectures promise solutions to...
  3. Oligopoly pricing in congested networks In this paper we study the problem of oligopoly pricing in congested markets when the demand faced b...
  4. Structural and Dynamic Properties of Hexadecane Lubricants under Shear Flow in a Confined Geometry Using shear dynamics simulations we investigated the structure and dynamics of hexadecane (n-C_(16)H...
  5. Algorithm 371: Partitions in natural order [A1] [no abstract[

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.