Thursday, November 26, 2015



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso

Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and binding repertoire of GATA-3 and PU.1, transcription factors with complementary roles in T cell development. The results highlight potential promoter-distal cis-regulatory elements in play and reveal both activation sites and diverse mechanisms of repression that silence genes used in alternative lineages. Histone marking is dynamic and reversible, and though permissive marks anticipate, repressive marks often lag behind changes in transcription. In vivo binding of PU.1 and GATA-3 relative to epigenetic marking reveals distinctive factor-specific rules for recruitment of these crucial transcription factors to different subsets of their potential sites, dependent on dose and developmental context.

Autor(es): Zhang, Jingli A. -  Mortazavi, Ali -  Williams, Brian A. -  Wold, Barbara J. -  Rothenberg, Ellen V. - 

Id.: 55304949

Versión: 1.0

Estado: Final

Tipo:  application/ -  application/ -  application/ -  application/ -  application/ -  text/xml -  application/pdf -  application/ -  image/png - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/ -  application/ -  application/ -  application/ -  application/ -  text/xml -  application/pdf -  application/ -  image/png - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References]

Fecha de contribución: 27-dic-2012


* Zhang, Jingli A. and Mortazavi, Ali and Williams, Brian A. and Wold, Barbara J. and Rothenberg, Ellen V. (2012) Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity. Cell, 149 (2). pp. 467-482. ISSN 0092-8674

Otros recursos del mismo autor(es)

  1. A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells



    In Arabidopsis thaliana, the gene Tousled enc...

  2. What do we know about who does and does not attend general health checks? Findings from a narrative scoping review



    General and preventive health checks are a key feature of conte...

  3. Mining gene expression data by interpreting principal components



    There are many methods for analyzing microarray data that group...

  4. Predictors of condom use and refusal among the population of Free State province in South Africa



    This study investigated the extent and predictors of condom use...

  5. Health in the 'hidden population' of people with low literacy. A systematic review of the literature



    Much of the evidence of an association between low functional o...

Otros recursos de la misma colección

  1. On the Simple Tensile Deformation of an Incompressible Rubber Matrix Filled with Non-Adherent Rigid Spheres of Uniform Size Distribution Two striking features revealed in a photograph (cf Figure 1) of a thin film of rubber binder highly ...
  2. Time-Dependent Failure of Viscoelastic Materials Under Cyclic Loads The problem of failure in viscoelastic materials under cyclic strain histories is treated theoretica...
  3. Fatigue Failure in Linearly Viscoelastic Masterials The thermodynamic approach to the fracture of linearly viscoelastic materials presented earlier is e...
  4. Transient Excitation of an Elastic Half Space by a Point Load Traveling on the Surface The propagation of transient waves in a homogeneous, isotropic, linearly elastic half space excited ...
  5. Three-Dimensional Stress Concentration Around a Cylindrical Hole in a Semi-Infinite Elastic Body This paper contains a three-dimensional solution, exact within classical elastostatics, for the stre...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.

Busque un recurso