Wednesday, August 20, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso   Descargar recurso

Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and binding repertoire of GATA-3 and PU.1, transcription factors with complementary roles in T cell development. The results highlight potential promoter-distal cis-regulatory elements in play and reveal both activation sites and diverse mechanisms of repression that silence genes used in alternative lineages. Histone marking is dynamic and reversible, and though permissive marks anticipate, repressive marks often lag behind changes in transcription. In vivo binding of PU.1 and GATA-3 relative to epigenetic marking reveals distinctive factor-specific rules for recruitment of these crucial transcription factors to different subsets of their potential sites, dependent on dose and developmental context.

Autor(es): Zhang, Jingli A. -  Mortazavi, Ali -  Williams, Brian A. -  Wold, Barbara J. -  Rothenberg, Ellen V. - 

Id.: 55304949

Versión: 1.0

Estado: Final

Tipo:  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  text/xml -  application/pdf -  application/vnd.ms-excel -  image/png - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  application/vnd.ms-excel -  text/xml -  application/pdf -  application/vnd.ms-excel -  image/png - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604
[References] http://authors.library.caltech.edu/31437/

Fecha de contribución: 27-dic-2012

Contacto:

Localización:
* Zhang, Jingli A. and Mortazavi, Ali and Williams, Brian A. and Wold, Barbara J. and Rothenberg, Ellen V. (2012) Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity. Cell, 149 (2). pp. 467-482. ISSN 0092-8674 http://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604


Otros recursos del mismo autor(es)

  1. A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
  2. Fully automated high-throughput chromatin immunoprecipitation for ChIP-seq: Identifying ChIP-quality p300 monoclonal antibodies Chromatin immunoprecipitation coupled with DNA sequencing (ChIP-seq) is the major contemporary metho...
  3. Large-Scale Quality Analysis of Published ChIP-seq Data ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on a genome-...
  4. Defining functional DNA elements in the human genome With the completion of the human genome sequence, attention turned to identifying and annotating its...
  5. A Specific Mathematical Form for Wien's Displacement Law as vmax/T = constant For Wien's displacement law in terms of frequency v and temperature T (vmax/T = constant) a specific...

Otros recursos de la misma colección

  1. Changes of lead and barium with time in California off-shore basin sediments During ancient times the natural deposition fluxes of lead which can be leached with dilute acid fro...
  2. Laboratory Studies on the Reactions between Chlorine, Sulfur Dioxide, and Oxygen: Implications for the Venus Stratosphere The title reaction was studied by photolyzing mixtures of Cl_2 and SO_2 with and without O_2 present...
  3. Photochemistry of the Stratosphere of Venus: Implications for Atmospheric Evolution The photochemistry of the stratosphere of Venus was modeled using an updated and expanded chemical s...
  4. A Note on the Variational Method of Stokes and DeMarcus for Radiative Transfer in Planetary Atmospheres A generalized functional which yields the Milne integral equation on variation and whose extremum va...
  5. A model for the shape of the Fourier amplitude spectrum of acceleration at high frequencies At high frequencies f the spectrum of S-wave accelerations is characterized by a trend of exponentia...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso