1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso


During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell behaviors are seen in the soma and germline. We used oogenesis to explore developmental roles of two important actin regulators: Enabled/VASP proteins and Capping protein. We found that Enabled plays an important role in cortical integrity of nurse cells, formation of robust bundled actin filaments in late nurse cells that facilitate nurse cell dumping, and migration of somatic border cells. During nurse cell dumping, Enabled localizes to barbed ends of the nurse cell actin filaments, suggesting its mechanism of action. We further pursued this mechanism using mutant Enabled proteins, each affecting one of its protein domains. These data suggest critical roles for the EVH2 domain and its tetramerization subdomain, while the EVH1 domain appears less critical. Enabled appears to be negatively regulated during oogenesis by Abelson kinase. We also explored the function of Capping protein. This revealed important roles in oocyte determination, nurse cell cortical integrity and nurse cell dumping, and support the idea that Capping protein and Enabled act antagonistically during dumping. Together these data reveal places that these actin regulators shape oogenesis

Pertenece a

ARCA - Access to Research and Communication Annals - IGC Repository  


Gates, J. -  Nowotarski, S.H. -  Yin, H. -  Mahaffey, J.P. -  Bridges, T. -  Herrera, C. -  Homem, C.C.F. -  Janody, F. -  Montell, D.J. -  Peifer, M. - 

Id.: 52879567

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveEna/VASP - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://www.sciencedirect.com/science/article/pii/S0012160609009993

Fecha de contribución: 08-jul-2016


* Gates,J, Nowotarski,S.H., Yin,H., Mahaffey,J.P., Bridges,T., Herrera,C., Homem, C.C.F., Janody, F., Montell, D.J., Peifer, M. (2009).” Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis“. Developmental Biology. 333(1): 90-107
* 0012-1606

Otros recursos del mismo autor(es)

  1. Updated search for long-lived particles decaying to jet pairs A search is presented for long-lived particles with a mass between 25 and 50GeV/c2 and a lifetime be...
  2. Measurement of CP observables in B ± → DK *± decays using two- and four-body D final states Measurements of CP observables in B ± → DK *± decays are presented, where D denotes a superposition ...
  3. χc1 and χc2 resonance parameters with the decays χc1,c2 → J/ψμ+μ- The decays χ c 1 → J / ψ μ + μ − and χ c 2 → J / ψ μ + μ − are observed and used to study the re...
  4. First observation of the rare purely baryonic decay B0 → pp¯ The first observation of the decay of a B 0 meson to a purely baryonic final state, B 0 → p ¯ p ,...
  5. Measurement of the B ± production cross-section in pp collisions at √s = 7 and 13 TeV No abstract available.

Otros recursos de la mismacolección

  1. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells This deposit is composed by the main article and supplementary files of the publication.
  2. dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis Proper organ patterning depends on a tight coordination between cell proliferation and differentiati...
  3. The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex The Drosophila transcriptional co-activator protein Yorkie and its vertebrate orthologs YAP and TAZ ...
  4. Requirements for Mediator Complex Subunits Distinguish Three Classes of Notch Target Genes at the Drosophila Wing Margin Spatial and temporal gene regulation relies on a combinatorial code of sequence-specific transcripti...
  5. A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis E-cadherin plays a pivotal role in epithelial cell polarity, cell signalling and tumour suppression....

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.