1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Opción 2: Descargar recurso

Opción 3: Descargar recurso

Detalles del recurso


Anti-retroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life-cycle. In addition, antibodies also have the potential to guide host immune effector cells to kill HIV-1 infected cells. Examination of the kinetics of HIV-1 suppression in infected individuals by passively administered 3BNC117, a broadly neutralizing antibody (bNAb), suggested that the effects of the antibody are not limited to free viral clearance and blocking new infection, but also include acceleration of infected cell clearance. Consistent with these observations, we find that bNAbs can target CD4+ T cells infected with patient viruses and decrease their in vivo half-lives by a mechanism that requires FcγR engagement in a humanized mouse model. The results indicate that passive immunotherapy can accelerate elimination of HIV-1 infected cells.

Pertenece a

DSpace at MIT  


Lu, C. -  L. -  Bournazos, S. -  Schoofs, T. -  Halper -  Stromberg, A. -  Horwitz, J. A. -  Nogueira, L. -  Golijanin, J. -  Gazumyan, A. -  Ravetch, J. V. -  Caskey, M. -  Nussenzweig, M. C. -  Murakowski, Dariusz Krzysztof -  Chakraborty, Arup K -  Sarkar, Debolina - 

Id.: 69632649

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  http://purl.org/eprint/type/JournalArticle  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Creative Commons Attribution-Noncommercial-Share Alike

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] PMC
[References] http://dx.doi.org/10.1126/science.aaf1279
[References] Science

Fecha de contribución: 12-feb-2017


* 0036-8075
* 1095-9203
* Lu, C.-L. et al. “Enhanced Clearance of HIV-1-Infected Cells by Broadly Neutralizing Antibodies against HIV-1 in Vivo.” Science 352.6288 (2016): 1001–1004.

Otros recursos del mismo autor(es)

  1. Riesgo de adicción al ejercicio en triatletas hombres amateur varones y su relación con variables de entrenamiento. [Risk of exercise addiction among male amateur triathletes and its relationship with training variables]. Debido a la creciente popularidad del triatlón a nivel amateur el objetivo de este estudio fue evalu...
  2. Essai d’une complémentation alimentaire au flushing et au steaming de brebis ouled djellal par la caroube This study aims to substitute a concentrate containing whole carob food to the concentrate containin...
  3. Inclusão de glicerina bruta em dietas para coelhos em crescimento The present study aimed to evaluate the performance of rabbits during growth fed diets containing di...
  4. Produção total de gases e degradabilidade in vitro de dietas com torta de girassol The objective was to determine the effect of increasing levels of sunflower crushed in ruminant diet...
  5. Post-hatching growth potential of dominant black and yaffa brown pullet chicks from different egg weights The study was conducted to determine the effect of egg size on post-hatching performance of pullet c...

Otros recursos de la mismacolección

  1. Surveys, simulation and single-cell assays relate function and phylogeny in a lake ecosystem Much remains unknown about what drives microbial community structure and diversity. Highly structure...
  2. Bound states in the continuum Bound states in the continuum (BICs) are waves that remain localized even though they coexist with a...
  3. Impact of urbanization patterns on the local climate of a tropical city, Singapore: An ensemble study The effect of urbanization and urbanization pattern on the thermal environment and local rainfall is...
  4. Optimal Time-Inconsistent Beliefs: Misplanning, Procrastination, and Commitment We develop a structural theory of beliefs and behavior that relaxes the assumption of time consisten...
  5. Multiple metabolisms constrain the anaerobic nitrite budget in the Eastern Tropical South Pacific The Eastern Tropical South Pacific is one of the three major oxygen deficient zones (ODZs) in the gl...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.