1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Opción 2: Descargar recurso

Opción 3: Descargar recurso

Detalles del recurso

Descripción

Anti-retroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life-cycle. In addition, antibodies also have the potential to guide host immune effector cells to kill HIV-1 infected cells. Examination of the kinetics of HIV-1 suppression in infected individuals by passively administered 3BNC117, a broadly neutralizing antibody (bNAb), suggested that the effects of the antibody are not limited to free viral clearance and blocking new infection, but also include acceleration of infected cell clearance. Consistent with these observations, we find that bNAbs can target CD4+ T cells infected with patient viruses and decrease their in vivo half-lives by a mechanism that requires FcγR engagement in a humanized mouse model. The results indicate that passive immunotherapy can accelerate elimination of HIV-1 infected cells.

Pertenece a

DSpace at MIT  

Autor(es)

Lu, C. -  L. -  Bournazos, S. -  Schoofs, T. -  Halper -  Stromberg, A. -  Horwitz, J. A. -  Nogueira, L. -  Golijanin, J. -  Gazumyan, A. -  Ravetch, J. V. -  Caskey, M. -  Nussenzweig, M. C. -  Murakowski, Dariusz Krzysztof -  Chakraborty, Arup K -  Sarkar, Debolina - 

Id.: 69632649

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  http://purl.org/eprint/type/JournalArticle  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Creative Commons Attribution-Noncommercial-Share Alike

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] PMC
[References] http://dx.doi.org/10.1126/science.aaf1279
[References] Science

Fecha de contribución: 12-feb-2017

Contacto:

Localización:
* 0036-8075
* 1095-9203
* Lu, C.-L. et al. “Enhanced Clearance of HIV-1-Infected Cells by Broadly Neutralizing Antibodies against HIV-1 in Vivo.” Science 352.6288 (2016): 1001–1004.
* OPEN_ACCESS_POLICY

Otros recursos de la mismacolección

  1. Spontaneous mirror-symmetry breaking induces inverse energy cascade in 3D active fluids Classical turbulence theory assumes that energy transport in a 3D turbulent flow proceeds through a ...
  2. Verstehen for Sociology: Comment on Watts Duncan Watts, in “Common Sense and Sociological Explanations” (AJS 120 [2014]: 313–51) has done our ...
  3. Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs Actors and associates often match on a few dimensions that matter most for the relationship at hand....
  4. Split cuts and extended formulations for Mixed Integer Conic Quadratic Programming We study split cuts and extended formulations for Mixed Integer Conic Quadratic Programming (MICQP) ...
  5. On the power of randomization in network interdiction In this paper, we introduce the randomized network interdiction problem that allows the interdictor ...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.