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Organophosphorus containing nerve agents (OP’s) are a threat to the general public due to their facile synthesis and high toxicity. The current methods for treatment require immediate intervention after exposure to the OP’s. We are proposing the use of prophylactic bioscavenger butyrylcholinesterase (BuChE) as a preventative measure against these weapons. In order to better understand the biodistribution of these bioscavengers, we want to append a tag that will allow for in vivo measurement of the distribution. The tag we propose to use is a tetrathiatriarylmethyl radical. These compounds are stable in biological systems and can be observed by electron paramagnetic resonance (EPR) spectroscopy. Previously, these trityl radicals have been successfully prepared and used as sensors for molecular oxygen in biological systems. Enclosed are reports of improved large-scale synthesis of three different types of substituted aryl radical systems.

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Marette, Anthony - 

Id.: 55093206

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveOrganophosphates - 

Tipo de recurso: Thesis  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] The Ohio State University. Department of Chemistry Undergraduate Research Theses; 2012

Fecha de contribución: 30-may-2012



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