1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

Organophosphorus containing nerve agents (OP’s) are a threat to the general public due to their facile synthesis and high toxicity. The current methods for treatment require immediate intervention after exposure to the OP’s. We are proposing the use of prophylactic bioscavenger butyrylcholinesterase (BuChE) as a preventative measure against these weapons. In order to better understand the biodistribution of these bioscavengers, we want to append a tag that will allow for in vivo measurement of the distribution. The tag we propose to use is a tetrathiatriarylmethyl radical. These compounds are stable in biological systems and can be observed by electron paramagnetic resonance (EPR) spectroscopy. Previously, these trityl radicals have been successfully prepared and used as sensors for molecular oxygen in biological systems. Enclosed are reports of improved large-scale synthesis of three different types of substituted aryl radical systems.

Pertenece a

The KnowledgeBank at OSU  

Autor(es)

Marette, Anthony - 

Id.: 55093206

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveOrganophosphates - 

Tipo de recurso: Thesis  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] The Ohio State University. Department of Chemistry Undergraduate Research Theses; 2012

Fecha de contribución: 30-may-2012

Contacto:

Localización:

Otros recursos que te pueden interesar

  1. Synergistic effects of chlorpyrifos with piperonyl butoxide (pbo) against the lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae) Objective: To investigate the co-toxicity and co-efficient activity of Chlorpyrifos (Dursban 20EC), ...
  2. Study on organophosphate poisoning analysis and pharmacotherapeutic outcome in tertiary care hospital Background: Organophosphate (OP) poisoning is the most common cause of poisoning and suicides in rur...
  3. Rodlet cells changes in Oreochromis niloticus in response to organophosphate pesticide and their relevance as stress biomarker in teleost fishes Rodlet cells are frequently found in teleost fishes and although their role in organisms is not comp...
  4. Organophosphate Insecticide Poisoning and Parkinsonism Extrapyramidal parkinsonism in a 14 year-old boy developed 5 days after the accidental ingestion of ...
  5. Organophosphate retinopathy Organophosphates have rarely been reported to cause various ocular sequelae including retinal degene...

Otros recursos de la misma colección

  1. Identification of novel Ras pathway genes using an inducible Drosophila tumor cell line The oncogenic form of Ras signaling is associated with 30% of human cancers, including 90% of pancre...
  2. How Does Manning's Roughness Coefficient Change with Varying Widths? The use of remote sensing technology is increasingly important in today’s society, especially with r...
  3. Transnational Criminalization and Cultural Violence: Salvadoran Deportees, the United States, and El Salvador Many of the 20,777 Salvadorans who are deported from the U.S. on average each year since 2007 haven’...
  4. Negative Emotion Does Not Hinder Expression of Implicit Learning in a Contextual Cueing Task The efficiency of everyday visual search has been shown by previous studies to depend heavily on the...
  5. How does predation risk affect aggression in the Lake Tanganyika cichlid, Julidochromis ornatus? Biodiversity worldwide is being threatened by human-induced rapid environmental change, including cl...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.