Detalles del recurso


The unfolded protein response (UPR) is a conserved intracellular signaling pathway that controls transcription of endoplasmic reticulum (ER) homeostasis related genes. Ethanol stress has been recently described as an activator of the UPR response in yeast Saccharomyces cerevisiae, but very little is known about the causes of this activation. Although some authors ensure that the UPR is triggered by the unfolded proteins generated by ethanol in the cell, there are studies which demonstrate that protein denaturation occurs at higher ethanol concentrations than those used to trigger the UPR. Here, we studied UPR after ethanol stress by three different approaches and we concluded that unfolded proteins do not accumulate in the ER under. We also ruled out inositol depletion as an alternative mechanism to activate the UPR under ethanol stress discarding that ethanol effects on the cell decreased inositol levels by different methods. All these data suggest that ethanol, at relatively low concentrations, does not cause unfolded proteins in the yeasts and UPR activation is likely due to other unknown mechanism related with a restructuring of ER membrane due to the effect of ethanol.

Pertenece a



Navarro Tapia, Elisabet -  Pérez Torrado, Roberto -  Querol, Amparo - 

Id.: 70715070

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveUnfolded protein response - 

Tipo de recurso: Artículo  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] MINECO/ICTI2013-2016/AGL2015-67504-C3-1-R
[References] Publisher's version
[References] Sí

Fecha de contribución: 06-dic-2017


* Frontiers in Microbiology 8: 383 (2017)
* 1664-302X
* 10.3389/fmicb.2017.00383

Otros recursos del mismo autor(es)

  1. Transcriptomic analysis of Saccharomyces cerevisiae x Saccharomyces kudriavzevii hybrids during low temperature winemaking [Background]: Although Saccharomyces cerevisiae is the most frequently isolated species in wine ferm...
  2. On the origins and industrial applications of Saccharomyces cerevisiae × Saccharomyces kudriavzevii hybrids Companies based on alcoholic fermentation products, such as wine, beer and biofuels, use yeasts to m...
  3. Saccharomyces cerevisiae show low levels of traversal across human endothelial barrier in vitro [Background]: Saccharomyces cerevisiae is generally considered safe, and is involved in the product...
  4. Potential benefits of the application of yeast starters in table olive processing 4 Páginas; 1 Figura
  5. The Human Enhancer Blocker CTC-binding Factor Interacts with the Transcription Factor Kaiso International audience

Otros recursos de la mismacolección

  1. An L-Fucose Operon in the Probiotic Lactobacillus rhamnosus GG Is Involved in Adaptation to Gastrointestinal Conditions l-Fucose is a sugar present in human secretions as part of human milk oligosaccharides, mucins, and ...
  2. Noroviral P-Particles as an In Vitro Model to Assess the Interactions of Noroviruses with Probiotics Noroviruses (NoVs) are the main etiologic agents of acute epidemic gastroenteritis and probiotic bac...
  3. Cold storage of ‘Manzanilla de Sevilla’ and ‘Manzanilla Cacereña’ mill olives from super-high density orchards 33 Páginas, 1 Tabla; 5 Figuras
  4. Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense African trypanosomiasis is a neglected parasitic disease that is still of great public health releva...
  5. Understanding the implications of current health trends on the aroma of wet and dry cured meat products Meat product aroma is affected by various meat processing factors. In this review the main biochemic...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.