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INTRODUCTION: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by generalized areas of focal demyelination. The mainly used animal model is experimental autoimmune encephalomyelitis.OBJECTIVE: To demonstrate the effects of treatment with phycocyanobilin and their combinations. The PCB is a biliproteina derived from the cyanobacteria Spirulina platensis.METHODS: EAE was induced in mice C57BL / 6 with MOG35-55 in adjuvant full of Freund/emulsion of Mycobacterium tuberculosis and pertussis toxin. In this model was evaluated the effect of PCB/IFNbeta compared with the active ingredients in an independent way. The daily clinical progression was evaluated, and the concentrations of CCL5, CXCL10, IFN-γ, CXCL2, CCL2, IL-17A, IL-6 and IL-10 in homogenized tissue were determined by ELISA.RESULTS: EAE mice treated with the PCB/IFN-beta combination showed a significant decrease of the clinical score. On the other hand, PCB/IFN-beta combination treatment induced a significant decrease in the levels of IL-10 and IL-17 in homogenized's brain.CONCLUSION: The PCB/IFN-beta combination reduces the clinical progression of disease EAE, an effect possibly mediated in the brain by a decrease in the levels of IL-17A and IL-10.

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Autor(es)

Pavón Fuente, Nancy -  Pentón Rol, Giselle -  Marín Prida, Javier -  Lorigados Pedre, Lourdes -  Almaguer Melián, William -  Blanco Lezcano, Lisette - 

Id.: 69860544

Idioma: spa  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Palabras claveEsclerosis Múltiple - 

Tipo de recurso: text (article)  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

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Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] RCNN, ISSN 2225-4676, Vol. 6, Nº. 1, 2016 (Ejemplar dedicado a: Resúmenes de la Jornada de Neurología y Neurocirugía – NEUROSANTIAGO 2016)

Fecha de contribución: 22-may-2017

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* (Revista) ISSN 2225-4676

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