1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


Abstract Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to systematically assess the full spectrum of functional variation in protein coding gene regions on HIV-1 progression through exome sequencing of 1327 individuals. Genetic variants were tested individually and in aggregate across genes and gene sets for an influence on HIV-1 viral load. Results: Multiple single variants within the major histocompatibility complex (MHC) region were observed to be strongly associated with HIV-1 outcome, consistent with the known impact of classical HLA alleles. However, no single variant or gene located outside of the MHC region was significantly associated with HIV progression. Set-based association testing focusing on genes identified as being essential for HIV replication in genome-wide small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeats (CRISPR) studies did not reveal any novel associations. Conclusions: These results suggest that exonic variants with large effect sizes are unlikely to have a major contribution to host control of HIV infection.

Pertenece a

Digital Access to Scholarship at Harvard  


McLaren, Paul J -  Pulit, Sara L -  Gurdasani, Deepti -  Bartha, Istvan -  Shea, Patrick R -  Pomilla, Cristina -  Gupta, Namrata -  Gkrania -  Klotsas, Effrossyni -  Young, Elizabeth H -  Bannert, Norbert -  Del Amo, Julia -  Gill, M John -  Gilmour, Jill -  Kellam, Paul -  Kelleher, Anthony D -  Sönnerborg, Anders -  Zangerle, Robert -  Post, Frank A -  Fisher, Martin -  Haas, David W -  Walker, Bruce D -  Porter, Kholoud -  Goldstein, David B -  Sandhu, Manjinder S -  de Bakker, Paul I W -  Fellay, Jacques - 

Id.: 71228386

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveHIV/AIDS - 

Tipo de recurso: Journal Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: open

Requerimientos técnicos:  Browser: Any - 

Relación: [References] doi:10.1093/infdis/jix470
[References] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853944/pdf/
[References] The Journal of Infectious Diseases

Fecha de contribución: 21-abr-2018


* McLaren, P. J., S. L. Pulit, D. Gurdasani, I. Bartha, P. R. Shea, C. Pomilla, N. Gupta, et al. 2017. “Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.” The Journal of Infectious Diseases 216 (9): 1063-1069. doi:10.1093/infdis/jix470. http://dx.doi.org/10.1093/infdis/jix470.

Otros recursos del mismo autor(es)

  1. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors Host proteins are essential for HIV entry and replication and can be important nonviral therapeutic ...
  2. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart DiseaseNovelty and Significance Rationale: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstra...
  3. Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site Major advances in donor identification, antigen probe design, and experimental methods to clone path...
  4. Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape Recent studies have suggested greater HIV cure potential among infected children than adults. A majo...
  5. Engineering modular intracellular protein sensor-actuator devices Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to ...

Otros recursos de la mismacolección

  1. Prevalence and Framing of Health Disparities in Local Print News: Implications for Multilevel Interventions to Address Cancer Inequalities Background: Americans remain under-informed about cancer and other health disparities and the social...
  2. Opposite associations of household income with adolescent body mass index according to migrant status: Hong Kong’s “Children of 1997” birth cohort Background/objectives: In economically developed settings, household income is usually inversely ass...
  3. Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooc...
  4. Perfluorinated Alkyl Substances Perfluorinated alkyl substances have been in use for over sixty years, and these highly stable subst...
  5. Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort Perfluorinated alkylated substances (PFAS) are persistent industrial chemicals that have resulted in...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.