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Descripción

Trifluoroacetate salt contamination of peptides represents a challenging issue related to solid phase peptide synthesis and purification because it affects the chemical and biological properties of peptides. Purification of such materials is typically performed through a two-step post-synthetic procedure based on chromatography followed by ion exchange. For the first time, co-crystallization is presented in this study as a possible alternative and advantageous single-step method for the obtaining of TFA-free crystals of a dipeptide. A trifluoroacetate-contaminated L-Leu-L-Leu dipeptide has been used for co-crystallization experiments along with different solid coformers. New multicomponent crystals containing only the title compound and the second co-crystal formers are described in this work. Such results represent a novelty in the field of peptide chemistry and a valid proof for the use of crystal engineering-based method for a combined purification and crystallization strategy.

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Autor(es)

Lucaioli, Paolo -  Nauha, Elisa -  Singh, Ishwar -  Blagden, Nicholas - 

Id.: 70821190

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Palabras claveF151 Pharmaceutical Chemistry - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/30275/
[References] 10.1021/acs.cgd.7b01516

Fecha de contribución: 11-abr-2018

Contacto:

Localización:
* Lucaioli, Paolo and Nauha, Elisa and Singh, Ishwar and Blagden, Nicholas (2018) First steps for the direct purification of L-Leu-L-Leu dipeptide through co-crystallisation. Crystal Growth & Design, 18 (2). pp. 1062-1069. ISSN 1528-7483

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