1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

Since the discovery of nitrogen mustard as an effective anti-cancer agent in the 1940s, and consequently, the concept of chemotherapy, researchers around the world have been actively developing new and more effective chemotherapeutic agents to better treat cancer. Traditionally, chemotherapeutic agents work by interfering with cell division. However, by virtue of their mechanism of action, healthy normal cells can also be targeted and destroyed. As a result, while chemotherapy is an effective way of managing cancer, the resulting side effects limits its use. One approach currently taken to reduce these side effects is to deliver the chemotherapy drugs directly to the tumor via transarterial chemoembolization, or other similar procedures. While this has been effective in reducing systemic toxicity, more can be done to improve this. Ideally, a device that could sequester any unreacted chemotherapy agents could be installed "downstream" of the tumor prior to them entering systemic circulation. Such drug-capture materials have yet to be realized. We report the synthesis of genomic DNA functionalized 3D printed materials that can be used to capture doxorubicin, a commonly used chemotherapy agent. The efficacy of these materials highlight the possibility of utilizing them in a device that can be deployed in the body for drug capture.

Pertenece a

Caltech Authors  

Autor(es)

Yee, Daryl -  Schulz, Michael -  Blumenfeld, Carl -  Grubbs, Robert -  Greer, Julia - 

Id.: 71215972

Versión: 1.0

Estado: Final

Tipo de recurso: Conference or Workshop Item  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20180413-160844730
[References] https://authors.library.caltech.edu/85859/

Fecha de contribución: 14-abr-2018

Contacto:

Localización:
* Yee, Daryl and Schulz, Michael and Blumenfeld, Carl and Grubbs, Robert and Greer, Julia (2018) Genomic DNA functionalized 3D printed materials for drug capture. In: 255th American Chemical Society National Meeting & Exposition, March 18-22, 2018, New Orleans, LA. http://resolver.caltech.edu/CaltechAUTHORS:20180413-160844730

Otros recursos del mismo autor(es)

  1. Utility of a Ruthenium Metathesis Catalyst for the Preparation of End-Functionalized Polybutadiene The polymerization of cyclooctadiene (COD) in the presence of an allylic difunctionalized chain tran...
  2. Ruthenium Alkylidene Initiated Living Ring-Opening Metathesis Polymerization (ROMP) of 3-Substituted Cyclobutenes The synthesis and living ring-opening metathesis polymerization (ROMP) of substituted cyclobutenes w...
  3. Synthesis of Discotic Columnar Side-Chain Liquid Crystalline Polymers by Ring-Opening Metathesis Polymerization (ROMP) Discotic liquid crystalline polymers bearing alkoxy-substituted triphenylene moieties in the side-ch...
  4. Synthesis of Functionalized Polyethers by Ring-Opening Metathesis Polymerization of Unsaturated Crown Ethers A variety of polyethers were synthesized by a tandem approach incorporating ring-closing metathesis ...
  5. Synthesis of Poly(1,4-naphthylenevinylenes):  Metathesis Polymerization of Benzobarrelenes The syntheses of hexyl- and undecyl-substituted benzobarrelenes 10a,b are described. These molecules...

Otros recursos de la mismacolección

  1. Self-Assembled Monolayer Mechanism for Corrosion Inhibition of Iron by Imidazolines Some of the most effective corrosion inhibitors for oil field pipeline applications are the oleic im...
  2. Comparison of the Behavior of Several Cobalt Porphyrins as Electrocatalysts for the Reduction of O_2 at Graphite Electrodes Four cobalt porphyrins were adsorbed on graphite electrodes and used to catalyze the electroreductio...
  3. Molecular Recognition via Hydrogen Bonding at the Air−Water Interface:  An Isotherm and Fourier Transform Infrared Reflection Spectroscopy Study Molecular recognition in Langmuir monolayers at the air−water interface as a function of headgroup o...
  4. Diacetylene Chelator Lipids as Support for Immobilization and Imaging of Proteins by Atomic Force Microscopy Chelator lipids represent a powerful and flexible tool to immobilize, orient, and crystallize histid...
  5. Orienting DNA Helices on Gold Using Applied Electric Fields Gold surfaces modified with thiol-derivatized DNA duplexes have been investigated as a function of a...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.