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Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses

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Pertenece a: Document Server@UHasselt  

Descripción: Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems. Metals display a diverse array of physico-chemical properties such as essential versus non-essential and redox-active versus non-redox-active. In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health. In order to cope with different kinds of metals, plants possess defense strategies in which glutathione (GSH; gamma-glu-cys-gly) plays a central role as chelating agent, antioxidant and signaling component. Therefore, this review highlights the role of GSH in: (1) metal homeostasis; (2) antioxidative defense; and (3) signal transduction under metal stress. The diverse functions of GSH originate from the sulfhydryl group in cysteine, enabling GSH to chelate metals and participate in redox cycling.

Autor(es): JOZEFCZAK, Marijke -  REMANS, Tony -  VANGRONSVELD, Jaco -  CUYPERS, Ann - 

Id.: 55229043

Idioma: English  - 

Versión: 1.0

Estado: Final

Tipo:  31 -  application/pdf - 

Palabras clavemetals -  cellular redox state -  glutathione -  chelation - 

Tipo de recurso: Journal Contribution  -  Refereed  -  Review  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  31 -  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] 10.3390/ijms13033145
[References] 000302174500038

Fecha de contribución: 08-oct-2014

Contacto:

Localización:
* INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 132 (3), p. 3145-3175
* 1422-0067


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