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Descripción

Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes were associated with developmental alterations in oxytocinergic (OXT) neurons. Thus, otpa and otpb differentially regulate neuropeptide switching in a newly identified subset of OXT neurons that co-express the corticotropin-releasing hormone (CRH). Single-cell analysis revealed that these neurons project mostly to the hindbrain and spinal cord. Ablation of this neuronal subset specifically reduced adult social preference without affecting stress behavior, thereby uncoupling the contribution of a specific OXT cluster to social behavior from the general otpa(-/-) deficits. Our findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete OXT circuit whose disrupted development affects social behavior.

Pertenece a

Repositório do ISPA Instituto Superior de Psicologia Aplicada  

Autor(es)

Wircer, Einav -  Blechman, Janna -  Borodovsky, Nataliya -  Tsoory, Michael -  Nunes, Ana Rita -  Oliveira, Rui Filipe -  Levkowitz, Gil - 

Id.: 69690322

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveParaventricular nucleus - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] 1511/16
[References] 957/12
[References] 2137/16
[References] https://elifesciences.org/content/6/e22170

Fecha de contribución: 08-mar-2017

Contacto:

Localización:
* eLife, 6, 1-25. Doi: 10.7554/eLife.22170
* 2050-084X
* 10.7554/eLife.22170

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