1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso

Descripción

The conserved Hippo signaling pathway regulates multiple cellular events, including tissue growth, cell fate decision and neuronal homeostasis. While the core Hippo kinase module appears to mediate all the effects of the pathway, various upstream inputs have been identified depending on tissue context. We have recently shown that, in the Drosophila wing imaginal disc, actin-Capping Protein and Hippo pathway activities inhibit F-actin accumulation. In turn, the reduction in F-actin sustains Hippo pathway activity, preventing Yorkie nuclear translocation and the upregulation of proliferation and survival genes. Here, we investigate the role of Capping Protein in growth-unrelated events controlled by the Hippo pathway. We provide evidence that loss of Capping Protein induces degeneration of the adult Drosophila retina through misregulation of the Hippo pathway. We propose a model by which F-actin dynamics might be involved in all processes that require the activity of the core Hippo kinase module.

Pertenece a

ARCA - Access to Research and Communication Annals - IGC Repository  

Autor(es)

Brás -  Pereira, C. -  Zhang, T. -  Pignoni, F. -  Janody, F. - 

Id.: 54779744

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204144/?tool=pubmed

Fecha de contribución: 06-jul-2016

Contacto:

Localización:
* Brás-Pereira C, Zhang T, Pignoni F, Janody F. (2011).”Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway”. Communicative & Integrative Biology . 4(5):612-5
* 1942-0889

Otros recursos de la mismacolección

  1. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells This deposit is composed by the main article and supplementary files of the publication.
  2. dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis Proper organ patterning depends on a tight coordination between cell proliferation and differentiati...
  3. The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex The Drosophila transcriptional co-activator protein Yorkie and its vertebrate orthologs YAP and TAZ ...
  4. Requirements for Mediator Complex Subunits Distinguish Three Classes of Notch Target Genes at the Drosophila Wing Margin Spatial and temporal gene regulation relies on a combinatorial code of sequence-specific transcripti...
  5. A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis E-cadherin plays a pivotal role in epithelial cell polarity, cell signalling and tumour suppression....

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.