Detalles del recurso
An investigation of the Dakin-West reaction has been
made, as a result of which the scope of the reaction has been
extended in a number of ways.
a. It has been found that a number of aliphatic, aromatic
and heterocyclic acid anhydrides, acyl fluorides, and (with
the proper choice of catalysts) acid chlorides can be used in
place of acetic anhydride in the reaction. Several cyclic
anhydrides of dibasic acids have been shown not to react; inconclusive
results were obtained with maleic anhydride.
b. The reaction has been shown not to depend on a specific
catalytic action of the pyridine structure, but to be catalyzed
also by such bases as sodium acetate.
c. Several unusual α-amino acids have been shown to undergo
the reaction; conclusions have been drawn as to the failure of
several other amino acids to react. It has been shown that
dipeptides can be used in place of amino acids.
d. A mechanism for the reaction has been proposed, based
on evidence now available.
e. Observations have been made on side reactions of importance
to the reaction; a method of utility for purifying the
products of the reaction has been developed.
The role of peroxides in mutagenesis has been investigated;
several peroxides have proved to be effective for the
induction of mutations.
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Tipo de Interactividad: Expositivo
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Fecha de contribución: 07-oct-2017
* Cleland, George Horace (1951) I. An Investigation of the Dakin-West Reaction. II. The Role of Peroxides in Mutagenesis. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:10062017-132951069