Detalles del recurso
A new method for the determination of the structure of
polysaccharides has been proposed. A method for the benzylation of
sugars has been found, since the benzylation of the polysaccharides
is necessary as the first step in the proposed method.
In connection with the physiological action of organic fluorine
compounds, a number of fluorinated amino acids have been prepared.
The synthesis of 3-fluoro-dl-tyrosine, 3-fluoro-5-iodo-dl-tyrosine,
3-fluoro-dl-phenlalanine, 3'-fluoro-dl-thyronine, 3'-fluoro-3,5-
diiodo-dl-thyronine and 3'-fluoro-5'-iodo-3,5-diiodo-dl-thyronine
has been described.
In connection with the synthesis of 3,5-difluoro-dl-thyronine,
the preparation of the necessary starting materials has been
The synthesis of dl-3,5-diiodo-4-(3',5'diiodo-2'-hydroxy-phenoxy)-phenylalanine,
an isomer of thyroxine, is described. This
compound is physiologically active, the activity being approximately
one twenty-fifth of that of dl-thyroxine. This finding is in accordance
with a prediction relating thyroxine-like activity to chemical structure.
The attempted synthesis of dl-diiodo-4-(3',5'-diiodo-4'-
aminophenoxy)-phenylalanine is described.
The separation of the carotenoid, β-carotene, from bovine
spinal cord is described.
The separation of large amounts of cerebrodise-sphinogomylin
fraction from bovine spinal cord is described. The separation of
sphingosine and sphingosine derivatives, and reactions proposed to
lead to a determination of the structure of sphingosine are given.
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Fecha de contribución: 07-oct-2017
* Mead, James Franklyn (1942) I. The Benzylation of Carbohydrates. II. The Preparation of Fluorinated Analogues of Tyrosine and Thyronine. III. The Preparation of Isomers and Analogues of Thyroxine with Relation to a Proposed Hypothesis of the Relationship Between Structure and Thyroxine-Like Activity. IV. A Carotenoid from Bovine Spinal Cord. V. Studies on the Structure of Sphingosine. VI. The Length Muscles of the Holothurians (a Summary). Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:10062017-104405641