Tuesday, October 21, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


In vitro dissolution kinetics of Captopril from microspheres manufactured by solvent evaporation

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: Rhodes eResearch Repository  

Descripción: The aim of this study was to develop and assess captopril-loaded microspheres in which Methocel and Eudragit RS were used as release-controlling factors and to evaluate captopril (CPT) release using kinetic models. Drug-excipient interactions were evaluated using infrared studies, and the physical appearance was characterized using scanning electron microscopy (SEM). A burst effect was observed during the first stage of dissolution for most batches of microspheres. SEM results reveal that this may be attributed to dissolution of captopril crystals that were present on the surface, embedded in the superficial layer of the matrix materials, trapped near the surface of the microspheres, or that may have diffused rapidly through the porous surface of the capsules. The release data generated during in vitro release studies were fitted to zero-order, first-order, Higuchi, Korsmeyer–Peppas, Kopcha, and Makoid–Banakar models. The release kinetics of captopril from most formulations followed a classical Fickian diffusion mechanism. SEM photographs showed that diffusion took place through pores located in the surface of the microcapsules. The Kopcha model diffusion and erosion terms showed a predominance of diffusion relative to swelling or erosion throughout the entire test period. The drug release mechanism was also confirmed by the Makoid–Banakar and Korsmeyer–Peppas model exponents. This further supports a diffusion–release mechanism for most formulations. The models postulate that the total drug released is a summation of several mechanisms (viz., burst release, relaxation-induced controlled release, and diffusional release). These results also support the potential application of Eudragit/Methocel microspheres as a suitable sustained-release drug delivery system for captopril.

Autor(es): Khamanga, S.M.M. -  Walker, R.B. - 

Id.: 55201171

Versión: 1.0

Estado: Final

Tipo:  text - 

Palabras claveRS Pharmacy and materia medica - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  text - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://www.dissolutiontech.com/
[References] http://eprints.ru.ac.za/2601/

Fecha de contribución: 14-abr-2012

Contacto:

Localización:
* Khamanga, S.M.M. and Walker, R.B. (2012) In vitro dissolution kinetics of Captopril from microspheres manufactured by solvent evaporation. Dissolution Technologies, 19 (1). pp. 42-51. ISSN 1521-298X


Otros recursos del mismo autor(es)

  1. CONSEQUENT INTRAFAMILIAL IMMUNIZATION HAPLOTYPING IN CANINES* FOR DL-A The identification by lymphocyte cytotoxicity testing of a polymorphic "H" system of antig...
  2. Periodic magnetic field as a polarized and focusing thermal neutron spectrometer and monochromator A novel periodic magnetic field (PMF) optic is shown to act as a prism, lens, and polarizer for neut...
  3. Por que ler Hobbes como um teórico de segurança internacional? Thomas Hobbes tornou-se uma figura canônica para teorias de segurança internacional, ainda que seus ...
  4. The Changing Landscape of European Liberty and Security: Mid-Term Report on the Results of the CHALLENGE Project. CEPS CHALLENGE Paper, No. 4, 14 February 2007 The CHALLENGE project responds to widespread concerns about the resort to specific illiberal practic...
  5. The index of relative socio-economic disadvantage: general population views on indicators used to determine area-based disadvantage Copyright © 2005 Public Health Association Australia

Otros recursos de la misma colección

  1. The Evil of Sluits: A Re-assessment of Soil Erosion in the Karoo of South Africa as Portrayed in Century-Old Sources Deep, linear gullies are a common feature of the present landscape of the Karoo of South Africa, whe...
  2. Biopharmaceutics and pharmacokinetics of the macrolide antibiotic Josamycin The investigations detailed herein have been conducted to address various aspects of the biopharmace...
  3. SA Jazz Ensemble
  4. Sometimes black, sometimes white urges Africa to Mainz Open Ohr Festival
  5. Too hot in the tents for Africa

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso