1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


Background: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets. Results: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast and prostate cancer cells. SCD inhibition altered cellular lipid composition and impeded cell viability in the absence of exogenous lipids. SCD inhibition also altered cardiolipin composition, leading to the release of cytochrome C and induction of apoptosis. Furthermore, SCD was required for the generation of poly-unsaturated lipids in cancer cells grown in spheroid cultures, which resemble those found in tumour tissue. We also found that SCD mRNA and protein expression is elevated in human breast cancers and predicts poor survival in high-grade tumours. Finally, silencing of SCD in prostate orthografts efficiently blocked tumour growth and significantly increased animal survival. Conclusions: Our data implicate lipid desaturation as an essential process for cancer cell survival and suggest that targeting SCD could efficiently limit tumour expansion, especially under the metabolically compromised conditions of the tumour microenvironment.

Pertenece a



Peck, Barrie -  Schug, Zachary T. -  Zhang, Qifeng -  Dankworth, Beatrice -  Jones, Dylan T. -  Smethurst, Elizabeth -  Patel, Rachana -  Mason, Susan -  Jiang, Ming -  Saunders, Rebecca -  Howell, Michael -  Mitter, Richard -  Spencer -  Dene, Bradley -  Stamp, Gordon -  McGarry, Lynn -  James, Daniel -  Shanks, Emma -  Aboagye, Eric O. -  Critchlow, Susan E. -  Leung, Hing Y. -  Harris, Adrian L. -  Wakelam, Michael J. O. -  Gottlieb, Eyal -  Schulze, Almut - 

Id.: 69789650

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Tipo:  text - 

Tipo de recurso: Articles  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: cc_by_4

Formatos:  text - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.gla.ac.uk/139816/
[References] 10.1186/s40170-016-0146-8

Fecha de contribución: 24-may-2017


* Peck, B. et al. (2016) Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer and Metabolism , 4(1), 6. (doi:10.1186/s40170-016-0146-8 ) (PMID:27042297) (PMCID:PMC4818530)

Otros recursos del mismo autor(es)

  1. Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells Treatment of chronic myeloid leukemia (CML) with imatinib mesylate and other second- and/or third-ge...
  2. A note on Green functors with inflation This note is motivated by the problem to understand, given a commutative ring F, which G-sets X, Y g...
  3. First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data We report results of a deep all-sky search for periodic gravitational waves from isolated neutron st...
  4. A step toward paternalism : an address / Cover title.
  5. Song for June / "Songs with piano accompaniment by Wm. Spencer Johnson."-Cover.

Otros recursos de la mismacolección

  1. A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease Mutations in the park2 gene, encoding the RING-inBetweenRING-RING E3 ubiquitin ligase parkin, cause ...
  2. Choosing or refusing to take sides in an era of right-wing populism: part 2 No abstract available.
  3. Knowing and forgetting the Easter 1916 Rising The centenary of the Easter 1916 Rising was a source of both celebration and no little anxiety in Ir...
  4. Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for u...
  5. RBR E3 ubiquitin ligases: new structures, new insights, new questions The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.