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BACKGROUND: Compliance aids are devices which have been developed and are currently used to assist individuals in their medicines management. The use of compliance aids involves the transfer of medicines from the manufacturer’s original packaging and repackaged into an multi-compartment compliance aid (MCA). MCAs do not guarantee the same level of protection compared to manufacturer's original packaging. OBJECTIVE: The aim of this study was to investigate the stability profile of atenolol, aspirin and lansoprazole dosage forms repackaged together in two different commercially available MCAs. METHODS: In a laboratory in the United Kingdom, the physical stability of the formulations repackaged into two commercially available brands of MCAs was evaluated. After 8 weeks of storage (under controlled ambient conditions), changes in the disintegration (tablets only) and dissolution properties (all formulations) were examined in accordance with British Pharmacopoeia (BP) specifications. KEY FINDINGS: Findings from this study confirm that changes in solid dosage form quality are observed when repackaged into MCAs compared to manufacturers packaging resulting in differences in in vitro dissolution performance. However, even with these changes overall product performance was acceptable and within BP specifications. CONCLUSION: There is a need for greater collaboration in this area between manufacturers, hospital and community pharmacists, academics and policy makers to increase the data available on the physical stability and in turn performance of medicines repackaged into MCAs.

Pertenece a

UCL University College London Eprints  


Raimi -  Abraham, BT -  del Valle, AG -  Galcera, CV -  Barker, SA -  Orlu, M - 

Id.: 69787035

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveCompliance, MCA, older patient, repackaging, stability - 

Tipo de recurso: Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] Journal of Pharmaceutical Health Services Research (2017) (In press).

Fecha de contribución: 13-abr-2017



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