Friday, February 12, 2016

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing the most autoimmune disease-associated SNPs, appears to behave as a regulatory sequence, affecting the expression of a neighbouring gene, DEXI. The CLEC16A alleles that are protective from T1D and MS are associated with increased expression of DEXI, and no other genes in the region, in two independent monocyte gene expression data sets. Critically, using chromosome conformation capture (3C), we identified physical proximity between the DEXI promoter region and intron 19 of CLEC16A, separated by a loop of >150 kb. In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A. Intron 19 of CLEC16A is highly enriched for transcription-factor-binding events and markers associated with enhancer activity. Taken together, these data indicate that although the causal variants in the 16p13 region lie within CLEC16A, DEXI is an unappreciated autoimmune disease candidate gene, and illustrate the power of the 3C approach in progressing from genome-wide association studies results to candidate causal genes.

Autor(es): Davison, Lucy J. -  Wallace, Chris -  Cooper, Jason D. -  Cope, Nathan F. -  Wilson, Nicola K. -  Smyth, Deborah J. -  Howson, Joanna M.M. -  Saleh, Nada -  Al -  Jeffery, Abdullah -  Angus, Karen L. -  Stevens, Helen E. -  Nutland, Sarah -  Duley, Simon -  Coulson, Richard M.R. -  Walker, Neil M. -  Burren, Oliver S. -  Rice, Catherine M. -  Cambien, Francois -  Zeller, Tanja -  Munzel, Thomas -  Lackner, Karl -  Blankenberg, Stefan -  Fraser, Peter -  Gottgens, Berthold -  Todd, John A. - 

Id.: 55021020

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveArticles - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 11-feb-2012

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. Dificultades específicas en el aprendizaje de la lengua árabe por los hispanoparlantes
  2. Abdul Kalam Azad: Nasionalisme India MaulanaAbdul Kalam Muhyiddin Ahmad Azad ( 1888-1958 ) adalah seorang sarjana muslim dan pemimpin pol...
  3. Krisis Barat Modern Menurut Nasr Abad modern di Barat dimulai pada abad XVII, sekaligus merupakan awal kemenangan supremasi rasionali...
  4. Inhibition of DNA Topoisomerase Type IIα (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study
  5. Struktur Biaya dan Profitabilitas Usaha Tani Kacang Tanah di Desa Pulahenti Kecamatan Sumalata Kabupaten Gorontalo Utara This study aims to determine the cost structure of the peanut farm in the village of Pulahenti and t...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso