1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

BACKGROUND: Aminopeptidase P (APP) plays an important role in the catabolism of kinins in human plasma, mostly for des-Arg(9)-bradykinin. Impaired degradation of this active bradykinin metabolite was found to be associated with a decreased APP activity in hypertensive patients who experienced angioedema while being treated with angiotensin I-converting enzyme inhibitors. The pathophysiology of hereditary angioedema is presently attributed only to a quantitative/qualitative C1 inhibitor (CI-INH) defect with increased bradykinin release. OBJECTIVES: In the context of androgen prophylaxis, increased CI-INH function cannot fully explain protection from angioedema attacks alone because of the limited reversion of the CI-INH defects. Therefore we hypothesized that androgen prophylaxis could enhance plasma APP activity. METHODS: Patients with hereditary angioedema were investigated for plasma metallopeptidase activities responsible for kinin catabolism (APP, angiotensin I-converting enzyme, and carboxypeptidase N) and for CI-INH function in treated and untreated patients. RESULTS: APP activity was asymmetrically distributed in untreated patients (n = 147): the mean value was significantly lower than the value in a reference healthy and unmedicated population (n = 116; P < or = .001). Prophylaxis with androgen induced a significant increase in APP activity (P < or = .001), whereas it did not affect the other metallopeptidase activities. In both patient groups, APP activity showed a significant inverse relationship to disease severity (P < or = .001). CONCLUSION: In addition to the effect on circulating CI-INH levels, the increase in APP levels brought on by androgens could contribute to a more effective control of the kinin accumulation considered to be responsible for the symptoms of angioedema.

Pertenece a

Archive EduTice a CCSD electronic archive server based on P.A.O.L  

Autor(es)

Drouet, Christian -  Désormeaux, Anik -  Robillard, Josée -  Ponard, Denise -  Bouillet, Laurence -  Martin, Ludovic -  Kanny, Gisèle -  Moneret -  Vautrin, Denise -  Anne -  Bosson, Jean -  Luc -  Quesada, Jean -  Louis -  López -  Trascasa, Margarita -  Adam, Albert - 

Id.: 70446821

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras clave[SDV.EE.SANT] Life Sciences [q -  bio]/Ecology, environment/Health - 

Tipo de recurso: info:eu-repo/semantics/article  -  Journal articles  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] ISSN: 0091-6749
[IsBasedOn] Journal of Allergy and Clinical Immunology
[IsBasedOn] https://hal.archives-ouvertes.fr/hal-00281331
[IsBasedOn] Journal of Allergy and Clinical Immunology, Elsevier, 2008, 121 (2), pp.429-33. 〈10.1016/j.jaci.2007.10.048〉
[References] info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaci.2007.10.048
[References] info:eu-repo/semantics/altIdentifier/pmid/18158172

Fecha de contribución: 20-nov-2017

Contacto:

Localización:
* hal-00281331
* DOI : 10.1016/j.jaci.2007.10.048
* PUBMED : 18158172

Otros recursos de la mismacolección

  1. Clinically related protein-peptide interactions monitored in real time on novel peptide chips by surface plasmon resonance imaging. International audience
  2. Delta activity independent of its activity as a ligand of Notch. BACKGROUND: Delta, Notch, and Scabrous often function together to make different cell types and refi...
  3. SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populations. Sensorineural hearing loss is the most frequent sensory deficit of childhood and is of genetic origi...
  4. Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. BACKGROUND: The over-expression of transforming growth factor beta-1(TGF-beta1) has been reported to...
  5. [Evaluation of the risk of abortion abuse resulting from the two-week legal delay in France]. A national consensus on foetal abnormalities to be searched for, and not to be searched for (Number ...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.