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Detalles del recurso

Descripción

There is a convergence between the needs of the medical community and the capabilities of the engineering community. For example, the scale of biomedical devices and sensors allow for finer, more cost-effective quantification of biological and chemical targets. By using micro-fabrication techniques, we design and demonstrate a variety of microfluidic sensors and actuators that allow us to interact with a biochemical environment. We demonstrate the performance of microfluidic blood-filtrations chips, immune-diagnostic assays, and evaporative coolers. Furthermore, we show how micro-fabricated platinum filaments can be used for highly localized heating and temperature measurement. We demonstrate that these filaments can be used as miniature IR spectroscopic sources. Finally, we describe and demonstrate novel combinatorial coding methods for increasing the information extracted from biochemical reactions. We show proof-principle of these techniques in the context of Taqman PCR as well as persistence length PCR.

Pertenece a

CaltechTHESIS  

Autor(es)

Rajagopal, Aditya - 

Id.: 69702369

Versión: 1.0

Estado: Final

Tipo de recurso: Thesis  -  NonPeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechTHESIS:06052014-214022941
[References] http://thesis.library.caltech.edu/8491/

Fecha de contribución: 11-mar-2017

Contacto:

Localización:
* Rajagopal, Aditya (2014) Microfabricated Tools and Engineering Methods for Sensing Bioanalytes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9W9575D. http://resolver.caltech.edu/CaltechTHESIS:06052014-214022941

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  1. Supercolor Coding Methods for Large-Scale Multiplexing of Biochemical Assays We present a novel method for the encoding and decoding of multiplexed biochemical assays. The metho...
  2. Microfluidic blood filtration device Rapid decentralized biomedical diagnostics have become increasingly necessary in a medical environme...
  3. Microscaled and nanoscaled platinum sensors We show small and robust platinum resistive heaters and thermometers that are defined by microlithog...
  4. Evaporative cooling in microfluidic channels Evaporative cooling is an effective and energy efficient way to rapidly remove heat from a system. S...

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