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[Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n = 422) and IDC patients (n = 304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value = 0.040).

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Repositorio de la Universidade da Coruña. RUC  

Autor(es)

Fernández Caggiano, Mariana -  Barallobre -  Barreiro, Javier -  Rego Pérez, José Ignacio -  Crespo -  Leiro, María Generosa -  Paniagua -  Martín, María J. -  Grillé, Zulaika -  Blanco, F.J. -  Doménech, Nieves - 

Id.: 70089263

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveMitochondrial haplogroups - 

Tipo de recurso: info:eu-repo/semantics/article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Atribución-NoComercial-SinDerivadas 3.0 España

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://dx.doi.org/10.1016/j.mito.2013.03.005

Fecha de contribución: 14-jun-2018

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Localización:
* Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, et al. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in spanish population. Mitochondrion. 2013;13(4):263-268
* 1567-7249
* 1872-8278

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