1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

Nicotine activates plasma membrane (PM) nicotinic receptors (nAChRs), but also permeates into the endoplasmic reticulum (ER) and cis-Golgi, and there binds to nascent nAChRs. Other psychiatric and abused drugs may also enter the ER and bind their classical targets. Further progress requires direct proof, quantification, and time resolution of these processes in live cells and in the brain of animals. Therefore, we are developing genetically encoded fluorescent biosensors to study the subcellular pharmacokinetics of neural drugs.

Pertenece a

Caltech Authors  

Autor(es)

Shivange, Amol V. -  Nichols, Aaron L. -  Borden, Philip M. -  Kamjaya, Aron -  Muthusamy, Anand K. -  Jeon, Janice H. -  Unger, Elizabeth K. -  Tian, Lin -  Marvin, Jonathan S. -  Looger, Loren L. -  Lester, Henry A. - 

Id.: 70109812

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776
[References] http://authors.library.caltech.edu/81917/

Fecha de contribución: 30-sep-2017

Contacto:

Localización:
* Shivange, Amol V. and Nichols, Aaron L. and Borden, Philip M. and Kamjaya, Aron and Muthusamy, Anand K. and Jeon, Janice H. and Unger, Elizabeth K. and Tian, Lin and Marvin, Jonathan S. and Looger, Loren L. and Lester, Henry A. (2017) Nicotine in the Endoplasmic Reticulum. Journal of General Physiology, 149 (9). Art. No. 32. ISSN 0022-1295. http://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776

Otros recursos del mismo autor(es)

  1. Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala Alcohol and nicotine are two of the most frequently abused drugs, with their comorbidity well descri...
  2. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors (E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acet...
  3. Region specific proteomic analysis of murine brain after chronic nicotine or menthol Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels that are expressed in the ...
  4. The nicotinic 6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors International audience
  5. Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy Multi-day tracking of cells in culture systems can provide valuable information in bioscience experi...

Otros recursos de la mismacolección

  1. Designing a market for tradable emissions permits The purpose of this chapter is to investigate the practicality of a system of tractable emissions pe...
  2. Some core assumptions in development economics The purpose of this paper is three-fold. It seeks to outline "conventional" development economics. I...
  3. Toroidal plasmoid generation via extreme hydrodynamic shear Saint Elmo’s fire and lightning are two known forms of naturally occurring atmospheric pressure plas...
  4. Market power and transferable property rights The appeal of using markets as a means of allocating scarce resources stems in large part from the a...
  5. Nash equilibrium search for the best alternative In a recent paper, Weitzman (Econometrica 47 (1979) 641–654) described a policy of “optimal search f...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.