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[Background] The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remodeling are complex, and include hemodynamic and metabolic alterations that ultimately affect the functionality of the myocardium. G protein-coupled receptor kinase 2 (GRK2) is an ubiquitous kinase able to desensitize the active form of several G protein-coupled receptors (GPCR) and is known to play an important role in cardiac GPCR modulation. GRK2 has also been recently identified as a negative modulator of insulin signaling and systemic insulin resistance.

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Autor(es)

Lucas, Elisa -  Vila -  Bedmar, Rocío -  Arcones, Alba C. -  Cruces -  Sande, Marta -  Cachofeiro, Victoria -  Mayor Menéndez, Federico -  Murga, Cristina - 

Id.: 70878027

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveCardiac steatosis - 

Tipo de recurso: Artículo  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] MINECO/ICTI2013-2016/SAF2014-55511-R
[References] S2010/BMD-2332/INDISNET
[References] Publisher's version
[References] https://doi.org/10.1186/s12933-016-0474-6
[References] Sí

Fecha de contribución: 17-ene-2018

Contacto:

Localización:
* Cardiovascular Diabetology 15: 155 (2016)
* 1475-2840
* 10.1186/s12933-016-0474-6

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