1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis has been identified as a critical determinant of this process. However, there is evidence that portal venous pressure may begin to rise in the earliest stages of NAFLD when fibrosis is far less advanced or absent. The biological and clinical significance of these early changes in sinusoidal homeostasis remains unclear. Experimental and human observations indicate that sinusoidal space restriction due to hepatocellular lipid accumulation and ballooning may impair sinusoidal flow and generate shear stress, increasingly disrupting sinusoidal microcirculation. Sinusoidal endothelial cells, hepatic stellate cells, and Kupffer cells are key partners of hepatocytes affected by NAFLD in promoting endothelial dysfunction through enhanced contractility, capillarization, adhesion and entrapment of blood cells, extracellular matrix deposition, and neovascularization. These biomechanical and rheological changes are aggravated by a dysfunctional gut–liver axis and splanchnic vasoregulation, culminating in fibrosis and clinically significant portal hypertension. We may speculate that increased portal venous pressure is an essential element of the pathogenesis across the entire spectrum of NAFLD. Improved methods of noninvasive portal venous pressure monitoring will hopefully give new insights into the pathobiology of NAFLD and help efforts to identify patients at increased risk for adverse outcomes. In addition, novel drug candidates targeting reversible components of aberrant sinusoidal circulation may prevent progression in NAFLD.

Pertenece a

Digital Access to Scholarship at Harvard  

Autor(es)

Baffy, Gyorgy - 

Id.: 70979251

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveIntrahepatic vascular resistance - 

Tipo de recurso: Journal Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: open

Requerimientos técnicos:  Browser: Any - 

Relación: [References] 10.1007/s10620-017-4903-5
[References] Digestive Diseases and Sciences

Fecha de contribución: 10-feb-2018

Contacto:

Localización:
* Quick submit: 2018-01-24T09:27:27-0500
* Baffy, Gyorgy. 2018. “Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease.” Digestive Diseases and Sciences (January 22). doi:10.1007/s10620-017-4903-5.
* 0163-2116

Otros recursos del mismo autor(es)

  1. Uncoupling protein-2 and non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) has become the most common form of hepatic disorders in th...
  2. Complexity and network dynamics in physiological adaptation: An integrated view Living organisms constantly interact with their surroundings and sustain internal stability against ...
  3. The Impact of Network Medicine in Gastroenterology and Hepatology In the footsteps of groundbreaking achievements made by biomedical research, another scientific revo...
  4. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress
  5. Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice

Otros recursos de la mismacolección

  1. Adverse obstetric outcomes during delivery hospitalizations complicated by suicidal behavior among US pregnant women Objective: The effects of suicidal behavior on obstetric outcomes remain dangerously unquantified. W...
  2. Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study Background: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, ...
  3. ZINC AND MULTIVITAMIN SUPPLEMENTATION HAVE CONTRASTING EFFECTS ON INFANT IRON STATUS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL BACKGROUND Zinc supplementation adversely affects iron status in animal and adult human studies but ...
  4. Does early vitamin B12 supplementation improve neurodevelopment and cognitive function in childhood and into school age: a study protocol for extended follow-ups from randomised controlled trials in India and Tanzania Introduction: As many as 250 million children under the age of 5 may not be reaching their full deve...
  5. Change in alcohol intake in relation to weight change in a cohort of United States men with 24 years of follow-up Objective: We sought to prospectively investigate potential effects of alcohol by subtype on reporte...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.