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[Abstract] Background: Peritoneal protein excretion (PPE) is a potential marker of the outcome in peritoneal dialysis (PD) patients. Method: Observational study of a cohort of 269 patients starting PD in a single unit. Study variables: total PPE during a baseline peritoneal equilibration test (PET; PET-PPE) and 24-hour PPE. Control variables: essential baseline demographic, laboratory and adequacy markers. Main outcomes: mortality, cardiovascular events and risk of peritonitis. We applied univariate and multivariate strategies of survival analysis. Main Results: PET-PPE sustained a significant, yet limited correlation with 24-hour PPE (r = 0.46, p < 0.0005). At baseline, the main study variables showed an independent correlation with peritoneal transport characteristics (D/P240’ creatinine) and cardiovascular comorbidity. PET-PPE (p < 0.0005, model global χ2 59.4) was a more accurate predictor of overall mortality than 24-hour PPE (p = 0.04, χ2 50.5). Moreover, PPE during PET, but not 24-hour PPE, was an independent predictor of the risks of cardiovascular and infectious mortality, and of peritonitis. Conclusions: Baseline PPE represents a strong independent marker of survival of PD patients. Estimation of PPE during PET is more accurate than 24-hour PPE for this purpose, sustains a definite independent association with cardiovascular and infectious mortality, and shows a significant correlation with the risk of peritonitis.

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Repositorio de la Universidade da Coruña. RUC  

Autor(es)

Pérez Fontán, Miguel -  Rodríguez Carmona, Ana -  Barreda, D. -  López -  Muñiz, Andrés -  Blanco -  Castro, N. -  García Falcón, María Teresa - 

Id.: 69950837

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras clavePeritoneal equilibration test - 

Tipo de recurso: info:eu-repo/semantics/article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: info:eu-repo/semantics/openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://dx.doi.org/10.1159/000314659

Fecha de contribución: 29-ago-2017

Contacto:

Localización:
* Pérez-Fontán M, Rodríguez-Carmona A, Barreda D. López-Muñiz A, Blanco-Castro N, García-Falcón T. Peritoneal protein transport during the baseline peritoneal equilibration test is an accurate predictor of the outcome of peritoneal dialysis patients. Nephron Clin Pract. 2010;116(2):104-113
* 1660-2110
* 1660-8151

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