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[Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication. Methods. HIV-infected patients on follow-up at a reference hospital in north-west Spain were selected. DNA was isolated from plasma samples and mtDNA levels were assessed using a quantitative real-time PCR assay. HIV-RNA levels and CD4+ cell counts were evaluated in the same blood samples used for plasma mtDNA quantification. Epidemiological and clinical variables were included for the analysis. Results. A total of 235 HIV-infected patients were included. Mean plasma mtDNA levels were 217 ± 656 copies/μL for naive (31.9%) and 364 ± 939 copies/μL for HIV-infected patients receiving ART and with suppressed viraemia (P = 0.043). Among the latter, mean plasma mtDNA levels were 149 ± 440 copies/μL for those with low-level viraemia (LLV; HIV-RNA 20–200 copies/mL), 265 ± 723 copies/μL for those with detected-not-quantified (DNQ) viraemia (HIV-RNA <20 copies/mL) and 644 ± 1310 copies/μL for those with not-detected (ND) viraemia. Of note, a linear trend (P = 0.006) was observed among virologically suppressed (LLV, DNQ and ND) patients. ND patients had higher mtDNA levels compared with LLV patients (P = 0.057). Moreover, mtDNA levels were inversely associated with HIV-RNA levels (Spearman’s rho −0.191, P = 0.003) and directly associated with CD4+ counts (Spearman’s rho 0.131, P = 0.046). Conclusions. Increased plasma mtDNA levels are associated with lower HIV-RNA levels and higher CD4+ cell counts. Among ART-suppressed patients, mtDNA levels were significantly higher in those with complete virological suppression (ND) than in those with LLV. These data suggest that plasma mtDNA levels might serve as a biomarker of residual HIV replication.

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Repositorio de la Universidade da Coruña. RUC  

Autor(es)

Pernas, Berta -  Rego -  Pérez, Ignacio -  Tabernilla, Andrés -  Balboa, Vanesa -  Relaño, Sara -  Grandal, Marta -  Crespo, Manuel -  Mena, Álvaro -  Castro -  Iglesias, Ángeles -  Blanco, Francisco J. -  Poveda, Eva - 

Id.: 71394641

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveHIV - 

Tipo de recurso: info:eu-repo/semantics/article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: This is a pre-copyedited, author-produced version of an article accepted for publication in "Journal of Antimicrobial Chemotherapy following peer review. The version of record is avaliable online at Oxford Academic web page.

Requerimientos técnicos:  Browser: Any - 

Relación: [References] https://doi.org/10.1093/jac/dkx272

Fecha de contribución: 13-jun-2018

Contacto:

Localización:
* Pernas B, Rego-Pérez I, Tabernilla A, Balboa V, Relaño S, Grandal M, et al. Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication. J Antimicrob Chemother. 2017;72(11):3159-3162
* 0305-7453
* 1460-2091

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