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Descripción

Potyviruses constitute the second largest genus of plant viruses and cause important economic losses in a large variety of crops; however, the atomic structure of their particles remains unknown. Infective potyvirus virions are long flexuous filaments where coat protein (CP) subunits assemble in helical mode bound to a monopartite positive-sense single-stranded RNA [(+)ssRNA] genome. We present the cryo-electron microscopy (cryoEM) structure of the potyvirus watermelon mosaic virus at a resolution of 4.0 Å. The atomic model shows a conserved fold for the CPs of flexible filamentous plant viruses, including a universally conserved RNA binding pocket, which is a potential target for antiviral compounds. This conserved fold of the CP is widely distributed in eukaryotic viruses and is also shared by nucleoproteins of enveloped viruses with segmented (−)ssRNA (negative-sense ssRNA) genomes, including influenza viruses.

Pertenece a

Digital.CSIC  

Autor(es)

Zamora, Miguel -  Méndez -  López, Eduardo -  Agirrezabala, Xabier -  Cuesta, Rebeca -  Lavín, José L. -  Sánchez -  Pina, M. Amelia -  Aranda, Miguel A. -  Valle, Mikel - 

Id.: 71529326

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo de recurso: Artículo  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] MINECO/ICTI2013-2016/BFU2015-66326-P
[References] MINECO/ICTI2013-2016/AGL2015-65838-R
[References] Publisher's version
[References] http://dx.doi.org/10.1126/sciadv.aao2182
[References] Sí

Fecha de contribución: 12-jul-2018

Contacto:

Localización:
* Science Advances 3(9): eaao2182 (2017)
* 10.1126/sciadv.aao2182
* 2375-2548

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