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Descripción

Telomere and telomerase are involved in cellular and organismal ageing and have been related to human diseases. Coronary artery disease is one of the most common age-related health problems in developed countries. Nevertheless, the specific role of cellular ageing in this process is still unclear. In this study, we analyze the possible prognostic value of telomere length and telomerase polymorphisms in a population of 150 middle aged males (mean age 62 ± 7) admitted for acute coronary syndrome who were followed up for more than 600 days. Peripheral blood samples were obtained and relative and comparative qPCR was used to measure telomere length and real time PCR to study the polymorphisms. Two prognostic combined events were defined. Long telomere length was revealed as an independent predictor (protector) of combined event presentation during long term follow up in our patients.

Pertenece a

Digital.CSIC  

Autor(es)

Pérez -  Rivera, José Ángel -  Pabón -  Osuna, Pedro -  Cieza -  Borrella, Clara -  Martín -  Herrero, Francisco -  González -  Porras, José R. -  Sarmiento, Rogelio - 

Id.: 70715038

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveCardiovascular prognosis - 

Tipo de recurso: Artículo  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: closedAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] Sí

Fecha de contribución: 05-dic-2017

Contacto:

Localización:
* doi: 10.1016/j.mad.2012.09.003
* issn: 0047-6374
* e-issn: 1872-6216
* Mechanisms of Ageing and Development 133(11-12): 695-697 (2012)
* 10.1016/j.mad.2012.09.003

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