Wednesday, September 2, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


A role for synGAP in regulating neuronal apoptosis.

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: The brain-specific Ras/Rap GTPase-activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II, which up-regulates its GTPase-activating activity. Thus, SynGAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap. Homozygous deletion of synGAP is lethal within the first few days after birth. Therefore, to study the functions of synGAP, we used the cre/loxP recombination system to produce conditional mice mutants in which gradual loss of synGAP begins at approximately 1 week, and usually becomes maximal by 3 weeks, after birth. The resulting phenotypes fall into two groups. In a small group, the level of synGAP protein is reduced to 20-25% of wild type, and they die at 2-3 weeks of age. In a larger group, the levels remain higher than approximately 40% of wild type, and they survive and remain healthy. In all mutants, however, an abnormally high number of neurons in the hippocampus and cortex undergo apoptosis, as detected by caspase-3 activation. The effect is cell autonomous, occurring only in neuronal types in which the synGAP gene is eliminated. The level of caspase-3 activation in neurons correlates inversely with the level of synGAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of synGAP. These data show that synGAP plays a role in regulation of the onset of apoptotic neuronal death.

Autor(es): Knuesel, Irene -  Elliott, Abigail -  Chen, Hong -  Jung -  Mansuy, Isabelle M. -  Kennedy, Mary B. - 

Id.: 55220451

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150
[References] http://authors.library.caltech.edu/30304/

Fecha de contribución: 10-abr-2015

Contacto:

Localización:
* Knuesel, Irene and Elliott, Abigail and Chen, Hong-Jung and Mansuy, Isabelle M. and Kennedy, Mary B. (2005) A role for synGAP in regulating neuronal apoptosis. European Journal of Neuroscience, 21 (3). pp. 611-621. ISSN 0953-816X. http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150


Otros recursos del mismo autor(es)

  1. A Dynamic Paradigm for Spectrally Efficient Half-Duplex Multi-Antenna Relaying Abstract—This paper presents a spectrally efficient protocol for half-duplex multi-relay systems in ...
  2. A note on q-nanlogue of Sándor’s functions Abstract The additive analogues of Pseudo-Smarandache, Smarandache-simple functions and their duals ...
  3. PAPER IN FOREFRONT Fast and sensitive DNA analysis using changes in the FRET signals of molecular beacons in a PDMS microfluidic channel Abstract A new DNA hybridization analytical method using a microfluidic channel and a molecular beac...
  4. COMPACT REAL HYPERSURFACES IN COMPLEX TWO-PLANE GRASSMANNIANS Abstract. In this paper we give some characterizations of real hypersur-faces of type A in complex t...
  5. Exploiting Adaptive Background Image and Dynamic Search Window for Fast Object Tracking Recently, due to the interest for personal safety, intelligent image recognition technology using th...

Otros recursos de la misma colección

  1. Rapid Environmental Quenching of Satellite Dwarf Galaxies in the Local Group In the Local Group, nearly all of the dwarf galaxies (M_(star) ≾ 10^9 M_⊙) that are satellites withi...
  2. The 2014 ALMA Long Baseline Campaign: An Overview A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to make accurate images w...
  3. A Luminous X-Ray Flare from the Nucleus of the Dormant Bulgeless Spiral Galaxy NGC 247 NGC 247 is a nearby late-type bulgeless spiral galaxy that contains an inactive nucleus. We report a...
  4. On the Mass-Metallicity-Star Formation Rate Relation for Galaxies at z ~ 2 Recent studies have shown that the local mass–metallicity (M*–Z) relation depends on the specific st...
  5. The Physical Nature of the Cosmic Accretion of Baryons and Dark Matter into Halos and Their Galaxies The cosmic accretion of both dark matter and baryons into halos is typically measured using some evo...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso