Saturday, October 25, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


A role for synGAP in regulating neuronal apoptosis.

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: The brain-specific Ras/Rap GTPase-activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II, which up-regulates its GTPase-activating activity. Thus, SynGAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap. Homozygous deletion of synGAP is lethal within the first few days after birth. Therefore, to study the functions of synGAP, we used the cre/loxP recombination system to produce conditional mice mutants in which gradual loss of synGAP begins at approximately 1 week, and usually becomes maximal by 3 weeks, after birth. The resulting phenotypes fall into two groups. In a small group, the level of synGAP protein is reduced to 20-25% of wild type, and they die at 2-3 weeks of age. In a larger group, the levels remain higher than approximately 40% of wild type, and they survive and remain healthy. In all mutants, however, an abnormally high number of neurons in the hippocampus and cortex undergo apoptosis, as detected by caspase-3 activation. The effect is cell autonomous, occurring only in neuronal types in which the synGAP gene is eliminated. The level of caspase-3 activation in neurons correlates inversely with the level of synGAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of synGAP. These data show that synGAP plays a role in regulation of the onset of apoptotic neuronal death.

Autor(es): Knuesel, Irene -  Elliott, Abigail -  Chen, Hong -  Jung -  Mansuy, Isabelle M. -  Kennedy, Mary B. - 

Id.: 55220451

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150
[References] http://authors.library.caltech.edu/30304/

Fecha de contribución: 25-abr-2012

Contacto:

Localización:
* Knuesel, Irene and Elliott, Abigail and Chen, Hong-Jung and Mansuy, Isabelle M. and Kennedy, Mary B. (2005) A role for synGAP in regulating neuronal apoptosis. European Journal of Neuroscience, 21 (3). pp. 611-621. ISSN 0953-816X http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150


Otros recursos de la misma colección

  1. On the Propagation of Maximally Dissipative Phase Boundaries in Solids This paper is concerned with the kinetics of propagating phase boundaries in a bar made of a special...
  2. On an integrodifferential equation arising in a theory of phase transitions in solids This note is concerned with some properties of an integrodifferential equation a rising in a continu...
  3. Shock induced formation of MgAl_2O_4 spinel from oxides The physics of mineral grain sliding, which occurs upon dynamic compression of rocks, is investigate...
  4. Thermal expansion of mantle and core materials at very high pressures The thermal expansivities (α) of MgO and high-pressure phases of CaO, CaMgSi_2O_6, and Fe at ultrahi...
  5. Impact Jetting of Geological Materials To understand jetting of earth materials, gabbro slabs (5 mm thick) were accelerated to 1.5-2 km sec...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso