1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Detalles del recurso


The brain-specific Ras/Rap GTPase-activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II, which up-regulates its GTPase-activating activity. Thus, SynGAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap. Homozygous deletion of synGAP is lethal within the first few days after birth. Therefore, to study the functions of synGAP, we used the cre/loxP recombination system to produce conditional mice mutants in which gradual loss of synGAP begins at approximately 1 week, and usually becomes maximal by 3 weeks, after birth. The resulting phenotypes fall into two groups. In a small group, the level of synGAP protein is reduced to 20-25% of wild type, and they die at 2-3 weeks of age. In a larger group, the levels remain higher than approximately 40% of wild type, and they survive and remain healthy. In all mutants, however, an abnormally high number of neurons in the hippocampus and cortex undergo apoptosis, as detected by caspase-3 activation. The effect is cell autonomous, occurring only in neuronal types in which the synGAP gene is eliminated. The level of caspase-3 activation in neurons correlates inversely with the level of synGAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of synGAP. These data show that synGAP plays a role in regulation of the onset of apoptotic neuronal death.

Pertenece a

Caltech Authors  


Knuesel, Irene -  Elliott, Abigail -  Chen, Hong -  Jung -  Mansuy, Isabelle M. -  Kennedy, Mary B. - 

Id.: 55220451

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150
[References] http://authors.library.caltech.edu/30304/

Fecha de contribución: 24-ago-2016


* Knuesel, Irene and Elliott, Abigail and Chen, Hong-Jung and Mansuy, Isabelle M. and Kennedy, Mary B. (2005) A role for synGAP in regulating neuronal apoptosis. European Journal of Neuroscience, 21 (3). pp. 611-621. ISSN 0953-816X. http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150

Otros recursos del mismo autor(es)

  1. BiodivERsA project VineDivers: Analysing interlinkages between soil biota and biodiversity-based ecosystem services in vineyards across Europe Zaller, Johann G.-- Trabajo presentado en la EGU General Assembly 2016 (European Geosciences Union),...
  2. Measurement of the production cross section for single top quarks in association with W bosons in proton-proton collisions at $\sqrt{s}=$ 13 TeV A measurement is presented of the associated production of a single top quark and a W boson in proto...
  3. Measurement of nuclear modification factors of $\Upsilon$(1S), $\Upsilon$(2S), and $\Upsilon$(3S) mesons in PbPb collisions at $\sqrt{s_{_\mathrm{NN}}} =$ 5.02 TeV The cross sections for $\Upsilon$(1S), $\Upsilon$(2S), and $\Upsilon$(3S) production in lead-lead (P...
  4. Constraints on models of scalar and vector leptoquarks decaying to a quark and a neutrino at $\sqrt{s}=$ 13 TeV The results of a previous search by the CMS Collaboration for squarks and gluinos are reinterpreted ...
  5. Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state with two b quarks and two $\tau$ leptons in proton-proton collisions at $\sqrt{s}=$ 13 TeV A search for an exotic decay of the Higgs boson to a pair of light pseudoscalar bosons is performed ...

Otros recursos de la mismacolección

  1. Pedestrian Detection: A Benchmark Pedestrian detection is a key problem in computer vision, with several applications including roboti...
  2. Sensitivity and discovery potential of the proposed nEXO experiment to neutrinoless double-β decay The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrin...
  3. Speckle nulling wavefront control for Palomar and Keck We present a speckle nulling code currently being used for high contrast imaging at the Palomar and ...
  4. VISIR Upgrade: all’s well that ends well We present an overview of the VISIR instrument after its upgrade and return to science operations. V...
  5. High-contrast spectroscopy testbed for segmented telescopes The High Contrast Spectroscopy Testbed for Segmented Telescopes (HCST) at Caltech is aimed at fillin...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.