1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

The brain-specific Ras/Rap GTPase-activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II, which up-regulates its GTPase-activating activity. Thus, SynGAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap. Homozygous deletion of synGAP is lethal within the first few days after birth. Therefore, to study the functions of synGAP, we used the cre/loxP recombination system to produce conditional mice mutants in which gradual loss of synGAP begins at approximately 1 week, and usually becomes maximal by 3 weeks, after birth. The resulting phenotypes fall into two groups. In a small group, the level of synGAP protein is reduced to 20-25% of wild type, and they die at 2-3 weeks of age. In a larger group, the levels remain higher than approximately 40% of wild type, and they survive and remain healthy. In all mutants, however, an abnormally high number of neurons in the hippocampus and cortex undergo apoptosis, as detected by caspase-3 activation. The effect is cell autonomous, occurring only in neuronal types in which the synGAP gene is eliminated. The level of caspase-3 activation in neurons correlates inversely with the level of synGAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of synGAP. These data show that synGAP plays a role in regulation of the onset of apoptotic neuronal death.

Pertenece a

Caltech Authors  

Autor(es)

Knuesel, Irene -  Elliott, Abigail -  Chen, Hong -  Jung -  Mansuy, Isabelle M. -  Kennedy, Mary B. - 

Id.: 55220451

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150
[References] http://authors.library.caltech.edu/30304/

Fecha de contribución: 24-ago-2016

Contacto:

Localización:
* Knuesel, Irene and Elliott, Abigail and Chen, Hong-Jung and Mansuy, Isabelle M. and Kennedy, Mary B. (2005) A role for synGAP in regulating neuronal apoptosis. European Journal of Neuroscience, 21 (3). pp. 611-621. ISSN 0953-816X. http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150

Otros recursos del mismo autor(es)

  1. Univariant assessment of the quality of images
  2. A Large Hadron Electron Collider at CERN This document provides a brief overview of the recently published report on the design of the Large ...
  3. On the Relation of the LHeC and the LHC The present note relies on the recently published conceptual design report of the LHeC and extends t...
  4. A 10 Gb/s 45 mW adaptive 60 GHz baseband in 65 nm CMOS
  5. A 10Gb/s 45mW adaptive 60GHz baseband in 65nm CMOS

Otros recursos de la mismacolección

  1. Evaluation of the Distribution Function of the Limited Information Maximum Likelihood Estimator The distributions of the Limited Information Maximum Likelihood estimator for the coefficient of one...
  2. A Dynamic Model of Research Contracting This article analyzes the behavior of a single firm that is engaged in R&D for a "sponsor." We show ...
  3. Efficient Reliance and Damage Measures for Breach of Contract This article considers a situation where the buyer or the seller of a good must engage in expenditur...
  4. Continuous Social Decision Procedures Classical social decision procedures are supposed to map lists of preference orderings into binary r...
  5. Presidential Coattails in Historical Perspective Two methods are used to measure presidential coattails in House elections in various electoral perio...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.