Sunday, February 14, 2016

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


A role for synGAP in regulating neuronal apoptosis.

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


Detalles del recurso

Pertenece a: Caltech Authors  

Descripción: The brain-specific Ras/Rap GTPase-activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II, which up-regulates its GTPase-activating activity. Thus, SynGAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap. Homozygous deletion of synGAP is lethal within the first few days after birth. Therefore, to study the functions of synGAP, we used the cre/loxP recombination system to produce conditional mice mutants in which gradual loss of synGAP begins at approximately 1 week, and usually becomes maximal by 3 weeks, after birth. The resulting phenotypes fall into two groups. In a small group, the level of synGAP protein is reduced to 20-25% of wild type, and they die at 2-3 weeks of age. In a larger group, the levels remain higher than approximately 40% of wild type, and they survive and remain healthy. In all mutants, however, an abnormally high number of neurons in the hippocampus and cortex undergo apoptosis, as detected by caspase-3 activation. The effect is cell autonomous, occurring only in neuronal types in which the synGAP gene is eliminated. The level of caspase-3 activation in neurons correlates inversely with the level of synGAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of synGAP. These data show that synGAP plays a role in regulation of the onset of apoptotic neuronal death.

Autor(es): Knuesel, Irene -  Elliott, Abigail -  Chen, Hong -  Jung -  Mansuy, Isabelle M. -  Kennedy, Mary B. - 

Id.: 55220451

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150
[References] http://authors.library.caltech.edu/30304/

Fecha de contribución: 10-abr-2015

Contacto:

Localización:
* Knuesel, Irene and Elliott, Abigail and Chen, Hong-Jung and Mansuy, Isabelle M. and Kennedy, Mary B. (2005) A role for synGAP in regulating neuronal apoptosis. European Journal of Neuroscience, 21 (3). pp. 611-621. ISSN 0953-816X. http://resolver.caltech.edu/CaltechAUTHORS:20120424-145452150


Otros recursos del mismo autor(es)

  1. Potential Use of Left Renal Vein Graft in Pancreaticoduodenectomy Combined with Long Segmental Resection of the Superior Mesenteric-Splenic-Portal Vein Confluence Context Various techniques for reconstruction after superior mesenteric-splenic-portal vein confluen...
  2. Quantification of Protein Levels in Single Living Cells Accurate measurement of the amount of specific protein a cell produces is important for investigatin...
  3. Isolation of Human Colon Stem Cells Using Surface Expression of PTK7 Insertion of reporter cassettes into the Lgr5 locus has enabled the characterization of mouse intest...
  4. Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity Stem-toxic small molecules have been developed to induce selective cell death of pluripotent stem ce...
  5. Zur geschichte der gegenreformation in Tirol ... Festschrift zu ehren der 29. Versammlung deutscher philologen und schulmänner.

Otros recursos de la misma colección

  1. Observation of Gravitational Waves from a Binary Black Hole Merger On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wa...
  2. Water content of a granite magma deduced from the sequence of crystallization determined experimentally with water-undersaturated conditions The sequence of crystallization in a biotite-granite from the Bohus batholith of Norway and Sweden, ...
  3. Hybridization of magmas above subducted oceanic crust Hydrous siliceous melts rising from subducted oceanic crust may experience hybridization with overly...
  4. Leukemia Inhibitory Factor Is a Key Signal for Injury-Induced Neurogenesis in the Adult Mouse Olfactory Epithelium The mammalian olfactory epithelium (OE) is composed of primary olfactory sensory neurons (OSNs) that...
  5. Subsolidus and liquidus phase relationships in the system CaO-SiO_2-CO_2 to 30 kbar with geological applications Mixtures of crystalline CaCO_3, Ca_2SiO_4, CaSiO_3, quartz, and spurrite were reacted between 7 and ...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso