1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Detalles del recurso


The aim of this study was to evaluate the influence of three chemically diverse polymers, namely hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) on the phase transformation of three carbamazepine (CBZ) cocrystals including carbamazepine–nicotinamide (CBZ–NIC), carbamazepine–saccharin (CBZ–SAC) and carbamazepine–cinnamic acid (CBZ–CIN) in solution and tablet-based formulations. Based on the solubility and powder dissolution studies, it is demonstrated that cocrystals can be easily formulated through a simple solution formulation or powder formulation to generate supersaturated concentrations and faster dissolution rates to overcome those drugs with solubility and/or dissolution limited bioavailability. However, a polymer-based CBZ cocrystal tablet formulation has not shown any advantage of an improved CBZ release rate compared with the formulation of CBZ III or physical mixtures of CBZ III and coformers. This is in contrast to the solution behaviours of CBZ cocrystals in the solubility and powder dissolution tests because crystallization of the stable solid form of CBZ dihydrate (CBZ DH) within the tablet has taken place, leading to a reduced drug release rate and incomplete release. The mechanism of a polymer inhibition effect on drug precipitation in solution has been elucidated through investigating the molecular interactions among CBZ, coformers and polymers in solution using infrared spectroscopy. Finally, a formulation strategy has been proposed to capture the significant advantages of cocrystals.

Pertenece a

White Rose Research Online  


Qiu, S -  Lai, J -  Guo, M -  Wang, K -  Lai, X -  Desai, U -  Juma, N -  Li, M - 

Id.: 68473998

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  NonPeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://dx.doi.org/10.1039/c6ce00263c
[References] http://eprints.whiterose.ac.uk/100504/

Fecha de contribución: 12-oct-2016


* Qiu, S, Lai, J, Guo, M, Wang, K, Lai, X, Desai, U, Juma, N and Li, M (2016) Role of polymers in solution and tablet-based carbamazepine cocrystal formulations. CrystEngComm, 18 (15). pp. 2664-2678. ISSN 1466-8033

Otros recursos del mismo autor(es)

  1. The basic physics of the binary black hole merger GW150914 The first direct gravitational-wave detection was made by the Advanced Laser Interferometer Gravitat...
  2. Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. Peer reviewed
  3. VizieR Online Data Catalog: Clouds in SEDIGISM science demonstration field (Schuller+, 2017) VizieR On-line Data Catalog: J/A+A/601/A124. Originally published in: 2017A&A...601A.124S
  4. Upper limits on gravitational waves from scorpius X-1 from a model-based cross-correlation search in advanced LIGO data We present the results of a semicoherent search for continuous gravitational waves from the low-mass...
  5. Modeling of a Complex-Shaped Underwater Vehicle International audience

Otros recursos de la mismacolección

  1. Numerical analysis of the heat transfer in an oscillatory flow around the heat exchangers of thermoacoustic systems Heat exchangers are considered to be critical components of thermoacoustic systems and their appropr...
  2. The Chinese Spy: Duplicity and Dissimulation in Goldsmith's Chinese Letters
  3. REDD+, transformational change and the promise of performance-based payments: A qualitative comparative analysis Reducing emissions from deforestation and forest degradation (REDD+) has emerged as a promising clim...
  4. Interaction of Ammonium Carbamate with Uranyl, Zirconium and Molybdate Containing PUREX Species
  5. Tactile Language for a Head-Mounted Sensory Augmentation Device Sensory augmentation is one of the most exciting domains for research in human-machine biohybridicit...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.