1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

Aims: Age-related macular degeneration (AMD), a major cause of legal blindness in the elderly, is associated with genetic and environmental risk factors, such as cigarette smoking. Recent evidence shows that cigarette smoke (CS) that contains high levels of potent oxidants preferably targets retinal pigment epithelium (RPE) leading to oxidative damage and apoptosis; however, the mechanisms are poorly understood. The present study aimed to investigate the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in CS-related RPE apoptosis. Results: ER stress and proapoptotic gene C/EBP homologous protein (CHOP) were induced in the RPE/choroid complex from mice exposed to CS for 2 weeks and in human RPE cells treated with hydroquinone, a potent oxidant found at high concentrations in CS. Suppressing ER stress or inhibiting CHOP activation by pharmacological chaperones or genetic approaches attenuated hydroquinone-induced RPE cell apoptosis. In contrast to enhanced CHOP activation, protein level of active X-box binding protein 1 (XBP1), a major regulator of the adaptive UPR, was reduced in hydroquinone-treated cells. Conditional knockout of XBP1 gene in the RPE resulted in caspase-12 activation, increased CHOP expression, and decreased antiapoptotic gene Bcl-2. Furthermore, XBP1-deficient RPE cells are more sensitive to oxidative damage induced by hydroquinone or NaIO3, a CS-unrelated chemical oxidant. Conversely, overexpressing XBP1 protected RPE cells and attenuated oxidative stress-induced RPE apoptosis. Innovation and Conclusion: These findings provide strong evidence suggesting an important role of ER stress and the UPR in CS-related oxidative injury of RPE cells. Thus, the modulation of the UPR signaling may provide a promising target for the treatment of AMD. Antioxid. Redox Signal. 20, 2091–2106.

Pertenece a

Faculty of Technology ePrints Service  

Autor(es)

Chen, C. -  Cano, M. -  Wang, J. J. -  Li, J. -  Huang, C. -  Yu, Q. -  Herbert, T. P. -  Handa, J. T. -  Zhang, S. X. - 

Id.: 70192893

Versión: 1.0

Estado: Final

Palabras claveB200 Pharmacology, Toxicology and Pharmacy - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/28216/
[References] 10.1089/ars.2013.5240

Fecha de contribución: 08-nov-2017

Contacto:

Localización:
* Chen, C. and Cano, M. and Wang, J. J. and Li, J. and Huang, C. and Yu, Q. and Herbert, T. P. and Handa, J. T. and Zhang, S. X. (2014) Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. Antioxidants and Redox Signaling, 20 (14). pp. 2091-2106. ISSN 1523-0864

Otros recursos de la mismacolección

  1. Working towards the co-operative university for the UK A blog post reporting on the Making the Co-operative University conference, Manchester, 9th November...
  2. ‘Destabilized perception’: narrative as network in the films of Adam Curtis The work of Adam Curtis is notably absent from critical discussion of the contemporary essay film. Y...
  3. Contaminant biotransport by Pacific salmon to Lake Michigan tributaries The Great Lakes are ideal systems for evaluating the synergistic components of environmental change,...
  4. Generations BB, X, Y, Z, α: the changing consumer in the hospitality industry This chapter set out to understand the key characteristics of the Baby Boom, Generation X, Generatio...
  5. The symbiotic relationship between unusual venues and street food commercial events: the case of Street Feast in London Through the analysis of Street Feast, a commercial street food event concept in London, the chapter ...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.