Detalles del recurso
Pertenece a:
Universidad Nacional de La Plata
Descripción: The solubility of lysine clonixinate (LysClon) in several ethanol + water mixtures was determined at 293.15 to 313.15 K. The thermodynamic functions, Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations.
In general this drug exhibit good solubility and the greatest value was obtained in the mixture 0.60 in mass
fraction of ethanol. A non-linear enthalpy–entropy relationship was observed from a plot of enthalpy vs.
Gibbs energy of solution. Accordingly, the driving mechanism for LysClon solubility in water-rich and
ethanol-rich mixtures is the entropy, probably due to water-structure losing around the drug non-polar
moieties by ethanol or increased ionic solvation; whereas, in the medium composition mixtures the driving
mechanism is the enthalpy, probably due to LysClon solvation increase by the co-solvent molecules.
Autor(es): Delgado, Daniel R. - Martínez, Fleming - Gutiérrez, Rahumir A. -
Id.: 55311573
Idioma:
inglés
-
Versión: 1.0
Estado: Final
Palabras clave: Cosolvency - Ethanol - Lysine clonixinate - Solubility - Solution thermodynamics -
Tipo de recurso:
Articulo
- Articulo
-
Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
Audiencia:
Estudiante
- Profesor
- Autor
-
Estructura: Atomic
Coste: no
Copyright: sí
Requerimientos técnicos: Browser: Any -
Relación:
[References] Latin American Journal of Pharmacy
[References] vol. 31, no. 02
Fecha de contribución: 30-dic-2012
Contacto:
Localización:
* 0326-2383
