1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

The frequency, age-onset and distribution of spontaneously deposited immunoglobulins (Igs) in glomeruli of Sprague-Dawley rats has been investigated. Groups of rats (n = 10) were examined at 4-7 day intervals from birth (presuckling) until 30 days of age. Findings were compared with circulating immunoglobulin concentrations in each age group. Immunoglobulins were undetectable in immature kidneys of newborn rats. However, as early as 5 days, scanty IgA and IgM deposits were observed predominantly in mesangial areas of mature glomeruli, corresponding to low circulating concentrations of these immunoglobulins. By contrast, glomerular IgG deposits were not observed until 21 days, despite relatively high concentrations of circulating maternal IgG from birth. Mesangial deposition of immunoglobulins increased with age. Absence of complement C3c or electron dense deposits associated with this mesangial localization suggests that immunoglobulins were not deposited as immune complexes. Accumulation of non-phlogogenic immunoglobulins in the mesangium of normal rats supports the concept that the mesangium is constantly perfused by circulating macromolecules and filtration residues. The results indicate problems of interpretation of the significance of endogenous immunoglobulin deposition in models of experimental glomerulonephritis, even in studies involving weanling rats.

Pertenece a

White Rose Research Online  

Autor(es)

Goode, NP -  Davison, AM -  Gowland, G -  Shires, M - 

Id.: 55211440

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  NonPeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.whiterose.ac.uk/43871/

Fecha de contribución: 20-feb-2016

Contacto:

Localización:
* Goode, NP, Davison, AM, Gowland, G and Shires, M (1988) Spontaneous glomerular immunoglobulin deposition in young Sprague-Dawley rats. Laboratory Animals, 22 (4). 287 - 292 . ISSN 0023-6772

Otros recursos de la misma colección

  1. A web-based and mobile health social support intervention to promote adherence to inhaled asthma medications: randomized controlled trial Background: Online communities hold great potential as interventions for health, particularly for th...
  2. The politics of drug control in Nigeria:exclusion, repression and obstacles to policy change Background International agencies have viewed West Africa as a major player in the global trade in c...
  3. Block sequential adriamycin CMF – optimal non-myeloablative chemotherapy for high risk adjuvant breast cancer? After the publication of the 10-year survival data from Milan on the adjuvant use of the block seque...
  4. Linking apoptosis to cancer metabolism: Another missing piece of JuNK Cancer cells become dependent on aerobic glycolysis to sustain rapid proliferation and escape apopto...
  5. Evaluating public involvement in research design and grant development: Using a qualitative document analysis method to analyse an award scheme for researchers Background: A regional Research Design Service, funded by the National Institute for Health Research...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.