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Achyrocline satureioides (AS, family Asteraceae) is a plant widely used in traditional medicine for stomach, digestive, and gastrointestinal disorders during pregnancy. Studies regarding the indiscriminate use of plant infusions during pregnancy are limited. Recent reports have shown that chronic flavonoid supplementation induces toxicity in vivo and raises the mortality rates of healthy subjects. Therefore, we investigated whether supplementation of pregnant and lactating Wistar rats with two AS inflorescence extracts, consisting of an aqueous (AQ) extract similar to a tea (47 mg kg 1 day) and a hydroethanolic (HA) extract (35 mg kg 1 day 1) with a higher flavonoid content, could induce redox-related side effects. Total reactive antioxidant potential (TRAP), thiobarbituric reactive species (TBARS), and total reduced thiol (SH) content were evaluated. Superoxide dismutase (SOD) and catalase (CAT) activities were additionally quantified. Our data suggest that both AQ and HA of AS inflorescence extracts may induce symptoms of toxicity in concentrations of (47 mg kg 1 day) and (35 mg kg 1 day 1), respectively, in mothers regarding the delivery index and further decrease of neonatal survival. Of note, significant tissue-specific changes in maternal (liver, kidney, heart, and hippocampus) and pups (liver and kidney) biochemical oxidative parameters were observed. Our findings provide evidence that may support the need to control supplementation with the AQ of AS inflorescence extracts during gestation due to potential toxicity in vivo, which might be related, at least in part, to changes in tissue-specific redox homeostasis and enzymatic activity.

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Lume, repositório digital da Universidade Federal do Rio Grande do Sul (UFRGS)  


Moresco, Karla Suzana -  Silveira, Alexandre Kleber -  Schnorr, Carlos Eduardo -  Zeidán -  Chuliá, Fares -  Bortolin, Rafael Calixto -  Bittencourt, Leonardo da Silva -  Mingori, Moara Rodrigues -  Heimfarth, Luana -  Rabelo, Thallita Kelly -  Morrone, Maurilio da Silva -  Carini, Juliana Poglia -  Gelain, Daniel Pens -  Bassani, Valquiria Linck -  Moreira, Jose Claudio Fonseca - 

Id.: 71022421

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Palabras claveAchyrocline satureioides - 

Tipo de recurso: Artigo de periódico  -  Estrangeiro  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Open Access

Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] Biomedicines. Basel. Vol. 5, no. 3 (Sep. 2017), Article 53, [14 p.]

Fecha de contribución: 22-feb-2018


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* 001059827

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