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Descripción

One focus of this presentation is on a water-soluble macrocycle and its ability to recognize differently methylated lysines. The results show that the host molecule discriminates lower methylated lysines, while higher methylated ones bind rather selectively. Binding studies were carried out with respectively methylated lysines using NMR spectroscopy and our findings have been analyzed by energy-minimization calculations. A second focus is on macrocycles with intrinsic fluorescence. We suggested the name ‘fluorescophane’ for such macrocyclic compounds. By inserting a condensed aromatic system, the resulting receptor is envisaged to enable better C−H···π and cation···π interactions with a respective alkyl ammonium ion and at the same time allow an efficient quantification of host/guest interactions.

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Autor(es)

Gruber, Tobias - 

Id.: 71074734

Versión: 1.0

Estado: Final

Palabras claveF151 Pharmaceutical Chemistry - 

Tipo de recurso: Conference or Workshop contribution  -  NonPeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/31282/

Fecha de contribución: 10-mar-2018

Contacto:

Localización:
* Gruber, Tobias (2018) Supramolecular receptors for the recognition and discrimination of epigenetically modified lysines. In: Chemiedozententagung 2018, 5 -7 March 2018, Jena, Germany.

Otros recursos del mismo autor(es)

  1. Supramolecular receptors for the recognition and discrimination of post-translationally methylated lysines (PT2) The understanding of gene regulation plays an important role in epigenetics, which describe the mole...
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  3. Different supramolecular interactions mediated by bromine atoms in the crystal structures of three anisole derivatives Three anisole building blocks featuring bishydroxymethyl or bisbromomethyl pendants have been analyz...
  4. Synthetic receptors for the recognition and discrimination of epigenetically modified lysines Synthetic receptors for the recognition and discrimination of epigenetically modified lysines
  5. Synthesis of a bicyclic oxo-gamma-lactam from a simple caprolactam derivative The synthesis of the 6-azabicyclo[3.2.1]octane ring system, via Dieckmann cyclization, is described....

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