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One focus of this presentation is on a water-soluble macrocycle and its ability to recognize differently methylated lysines. The results show that the host molecule discriminates lower methylated lysines, while higher methylated ones bind rather selectively. Binding studies were carried out with respectively methylated lysines using NMR spectroscopy and our findings have been analyzed by energy-minimization calculations. A second focus is on macrocycles with intrinsic fluorescence. We suggested the name ‘fluorescophane’ for such macrocyclic compounds. By inserting a condensed aromatic system, the resulting receptor is envisaged to enable better C−H···π and cation···π interactions with a respective alkyl ammonium ion and at the same time allow an efficient quantification of host/guest interactions.

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Faculty of Technology ePrints Service  


Gruber, Tobias - 

Id.: 71074734

Versión: 1.0

Estado: Final

Palabras claveF151 Pharmaceutical Chemistry - 

Tipo de recurso: Conference or Workshop contribution  -  NonPeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/31282/

Fecha de contribución: 10-mar-2018


* Gruber, Tobias (2018) Supramolecular receptors for the recognition and discrimination of epigenetically modified lysines. In: Chemiedozententagung 2018, 5 -7 March 2018, Jena, Germany.

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