1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso


A convenient and scalable synthesis of two unusual amino acid units found in dolastatin 16, dolaphenvaline, and dolamethylleuine, is described. Dolastatin 16, which was first isolated from the sea hare Dolabella auricularia by Pettit, exhibits not only strong inhibition of growth for a variety of human cancer cell lines but also potent antifouling activity against the larvae of the barnacle Balanus amphitrite. The key element of the synthesis is an organocatalytic Mannich reaction to construct two contiguous stereocenters in the amino acid units with almost complete enantio- and diastereoselectivity.

Pertenece a

Hokkaido University Collection of Scholarly and Academic Papers  


Umezawa, Taiki -  Sato, Akinori -  Ameda, Yasuto -  Casalme, Loida O. -  Matsuda, Fuyuhiko - 

Id.: 69981611

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras claveDolastatin 16 - 

Tipo de recurso: article (author version)  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: © 2014 Elsevier Ltd. All rights reserved.

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 21-oct-2017


* Tetrahedron letters, 56(1): 168-171

Otros recursos del mismo autor(es)

  1. Total synthesis and biological activity of dolastatin 16 The total synthesis of dolastatin 16, a macrocyclic depsipeptide first isolated from the sea hare Do...
  2. Design, Synthesis, and Antifouling Activity of Glucosamine-Based Isocyanides Biofouling, an undesirable accumulation of organisms on sea-immersed structures such as ship hulls a...
  3. Total synthesis of dolastatin 16 [an abstract of dissertation and a summary of dissertation review]
  4. Total synthesis of dolastatin 16 [an abstract of entire text] この博士論文全文の閲覧方法については、以下のサイトをご参照ください。
  5. Recent progress toward synthesis of chlorosulfolipids: total synthesis and methodology Chlorosulfolipids (CSLs) are an intriguing family of natural products featuring highly chlorinated l...

Otros recursos de la mismacolección

  1. The function of appendage patterning genes in mandible development of the sexually dimorphic stag beetle One of the defining features of the evolutionary success of insects is the morphological diversifica...
  2. Foraging responses of bumble bees to rewardless floral patches: importance of within-plant variance in nectar presentation Spatiotemporal variation in nectar distribution is a key factor affecting pollinator movements betwe...
  3. A framework for quantifying the relationship between intensity and severity of impact of disturbance across types of events and species Understanding the impacts of natural disturbances on wildlife populations is a central task for ecol...
  4. Environmental factors determining the distribution of highland plants at low-altitude algific talus sites Algific talus is a micro-scale habitat type where highland plants (subalpine and alpine species) are...
  5. Can preferred atmospheric circulation patterns over the North-Atlantic-Eurasian region be associated with arctic sea ice loss? In the framework of atmospheric circulation regimes, we study whether the recent Arctic sea ice loss...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.