1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 13); SO: SO rats without treatment (n = 13); and SO + CAA: SO rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAAadministration significantly increased catalase andGR activity (p < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.No significant differences were found between theRMRgroups in any of the parameters of renal function.However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

Pertenece a

Biblioteca Digital do IPB  


Nogueira, António José M. -  Peixoto, Francisco -  Oliveira, Maria Manuel -  Pires, Carlos André -  Colaço, Bruno -  Oliveira, Paula Alexandra -  Pires, Maria João - 

Id.: 70961758

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] info:eu-repo/grantAgreement/FCT/5876/147341/PT
[References] PTDC/DTP-DES/6077/2014

Fecha de contribución: 04-feb-2018


* Nogueira, António; Peixoto, Francisco; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula Alexandra; Pires, Maria João (2017) - The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction. BioMed Research International. ISSN 2314-6133. 2017, p.
* 2314-6133
* 10.1155/2017/5125980

Otros recursos del mismo autor(es)

  1. Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effect...
  2. Ultrasonographic evaluation of the kidney in 5/6 nephrectomized rats: Correlation with biochemical and histopathological findings To characterize the kidney alterations associated with renal mass reduction by two-dimensional ultra...
  3. “To learn, or to be the best?”: Achievement goal profiles in pre-adolescents This study aimed to examine the achievement goal orientation profiles of 5th and 7th grade students ...
  4. Assessment of microbiological contamination in different catering units related to food handling in the district of Bragança The catering industry has developed over time, increasing the concern about the health and nutrition...
  5. Assessment of iron and nitrates concentration in drinking water, in the district of Bragança, Portugal between 2012 and 2013 Water is an essential resource for life. It is a crucial factor for all living beings’ survival thus...

Otros recursos de la mismacolección

  1. Food Irradiation Chemistry The major components of food matrices are, apart from water, carbohydrates, proteins, and lipids, wh...
  2. Methods combined with irradiation for food preservation In recent years, consumers have been looking for safer, higher quality foods, but also more convenie...
  3. Chemical Methods Irradiation treatment might induce the formation of free radicals and other excited states of chemic...
  4. The increasing demand for functional foods Primitive societies often lack resources but have always emphasized the role of nutrition in maintai...
  5. Bioactive Compounds of Tomatoes as Health Promoters Tomato (Lycopersicon esculentum L.) is one of the most consumed vegetables in the world and probably...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.