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The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.

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Caltech Authors  

Autor(es)

Garg, Neil K. -  Sarpong, Richmond -  Stoltz, Brian M. - 

Id.: 69790715

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://resolver.caltech.edu/CaltechAUTHORS:20170414-143016727
[References] http://authors.library.caltech.edu/76576/

Fecha de contribución: 15-abr-2017

Contacto:

Localización:
* Garg, Neil K. and Sarpong, Richmond and Stoltz, Brian M. (2002) The First Total Synthesis of Dragmacidin D. Journal of the American Chemical Society, 124 (44). pp. 13179-13184. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20170414-143016727

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