1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Detalles del recurso


Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

Pertenece a



Schug, Zachary T. -  Vande Voorde, Johan -  Gottlieb, Eyal - 

Id.: 69789651

Versión: 1.0

Estado: Final

Tipo de recurso: Articles  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.gla.ac.uk/139817/
[References] 10.1038/nrc.2016.87

Fecha de contribución: 08-nov-2017


* Schug, Z. T., Vande Voorde, J. and Gottlieb, E. (2016) The metabolic fate of acetate in cancer. Nature Reviews Cancer , 16(11), pp. 708-717. (doi:10.1038/nrc.2016.87 ) (PMID:27562461)

Otros recursos del mismo autor(es)

  1. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 International audience
  2. Auto-commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-res...
  3. Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells Treatment of chronic myeloid leukemia (CML) with imatinib mesylate and other second- and/or third-ge...
  4. PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagati...
  5. Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation Background: Acute lymphoblastic leukaemia is the most common childhood cancer. Despite advances in t...

Otros recursos de la mismacolección

  1. Parkin function in Parkinson's disease Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized b...
  2. Crinoid phylogeny: response to a challenge Abstract: We respond to a paper entitled "When morphology meets molecular data in crinoid phylogeny:...
  3. Assessment of Materials and Processes for Resonant Electromechanical Devices No abstract available.
  4. Ultrasonic Transducers No abstract available.
  5. Searching for beauty-fully bound tetraquarks using lattice nonrelativistic QCD Motivated by multiple phenomenological considerations, we perform the first search for the existence...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.