1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


Stroke affects a large number of people, especially in developed countries, but treatment options are limited. Over the years, it has become clear that nitric oxide (NO) plays a major role in this pathology and that treatments that either reduce or increase NO presence may provide an alternative route for reducing the sequelae of brain ischemia. The NO donor LA 419 previously has been shown to protect the brain tissue from ischemic damage in an experimental model of global brain ischemia. Here we study whether this holds true for focal ischemia, a condition closer to the more common form of human stroke. Ischemia was induced in rats by a stereotaxic injection of endothelin-1, a potent vasoconstrictor, in the striatum. Seven days after the injection, magnetic resonance imaging (MRI) found a significant elevation in apparent diffusion coefficient (ADC) in the injected striatum of untreated rats, due to ischemia-induced vascular edema. Animals that received LA 419 prior to injection with endothelin-1 showed an ADC undistinguishable from the contralateral striatum or from the striatum of rats not treated with LA 419. In addition, immunohistochemistry with antibodies against neuronal nitric oxide synthase (nNOS), inducible NOS (iNOS), and nitrotyrosine showed a marked increase in the expression of these markers of NO production following ischemic treatment that was dampened by treatment with LA 419. In summary, our results clearly show that the NO donor LA 419 may be a useful compound for the prevention and/or treatment of focal brain ischemia. © 2007 Elsevier Ireland Ltd. All rights reserved.

Pertenece a



Martínez -  Murillo, Ricardo -  Fernández, A.P. -  Serrano, J. -  Rodrigo, J. Salas, E. -  Mourelle, M. -  Martínez, A. - 

Id.: 70131870

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveNitric oxide donor Focal ischemia nNOS iNOS Nitrotyrosine MRI - 

Tipo de recurso: Artículo  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: closedAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] Sí

Fecha de contribución: 19-dic-2017


* doi: 10.1016/j.neulet.2007.01.011
* issn: 0304-3940
* Neuroscience Letters 415: 149- 153 (2007)
* 10.1016/j.neulet.2007.01.011

Otros recursos del mismo autor(es)

  1. Antimicrobial properties and release of cinnamaldehyde in bilayer films based on polylactic acid (PLA) and starch [EN] Cinnamaldehyde (CIN) loaded amorphous PLA films were obtained by casting, using ethyl acetate a...
  2. Effectiveness of antibrowning agents applied by vacuum impregnation on minimally processed pear [EN] Different isotonic solutions containing antibrowning compounds (EDTA, 4-hexylresorcinol, citrat...
  3. Climate change adaptation measures in the management of natural and environmental risks (ClimRisk) The CLIMRisk project focuses on a specific transitional area (NUTS II), strategically located between...
  4. Seasonal and annual trends in field populations of Mediterranean fruit fly, Ceratitis capitata, in Mediterranean citrus groves: comparison of two geographic areas in eastern Spain [EN] Seasonal and annual trends in Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) populations...
  5. Low-Cost Diagnosis of Rotor Asymmetries in Induction Machines Working at a Very Low Slip Using the Reduced Envelope of the Stator Current [EN] Fault diagnosis of rotor asymmetries in induction machines working at a very low slip, through ...

Otros recursos de la mismacolección

  1. Expression and regulation of the methionine cycle genes in the mouse cochlea Póster presentado al XXXIX Congreso anual de la Sociedad Española de Bioquímica y Biología Molecular...
  2. The role of folic acid and omega-3 fatty acids in the interplay between nutrition and hearing loss Póster presentado al Cell Symposium: Aging and Metabolism, celebrado en Sitges (España) del 10 al 12...
  3. The interplay between nucleo/cytoplasmic distribution of methionine cycle enzymes and disease Póster presentado a la Conferencia de la Federation of American Societies for Experimental Biology (...
  4. PROTEIN KINASE C δ REGULATES THE CLEARANCE OF ACTIN AT THE IMMUNOLOGICAL SYNAPSE REQUIRED FOR POLARIZED EXOSOME SECRETION BY T CELLS Multivesicular bodies (MVB) enclose intraluminal vesicles (ILV) formed by inward budding from the me...
  5. Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor Clonal deletion in the thymus by apoptosis is involved in purging the immune system of self‐reactive...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.