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Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition.

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Lume, repositório digital da Universidade Federal do Rio Grande do Sul (UFRGS)  


Dietrich, Fabrícia -  Martins, Jerônimo Pietrobon -  Kaiser, Samuel -  Silva, Rodrigo Bradiccini Madeira da -  Rockenbach, Liliana -  Edelweiss, Maria Isabel Albano -  Ortega, George González -  Morrone, Fernanda Bueno -  Campos, Maria Martha -  Battastini, Ana Maria Oliveira - 

Id.: 71022420

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Palabras claveUnha de gato - 

Tipo de recurso: Artigo de periódico  -  Estrangeiro  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Open Access

Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] PLoS ONE. San Francisco. Vol. 10, no. 7 (Jul. 2015), 15 p., e0131882

Fecha de contribución: 22-feb-2018


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