1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

The Drosophila transcriptional co-activator protein Yorkie and its vertebrate orthologs YAP and TAZ are potent oncogenes, whose activity is normally kept in check by the upstream Hippo kinase module. Upon its translocation into the nucleus, Yorkie forms complexes with several tissue-specific DNA-binding partners, which help to define the tissue-specific target genes of Yorkie. In the progenitor cells of the eye imaginal disc, the DNA-binding transcription factor Homothorax is required for Yorkie-promoted proliferation and survival through regulation of the bantam microRNA (miRNA). The transit from proliferating progenitors to cell cycle quiescent precursors is associated with the progressive loss of Homothorax and gain of Dachshund, a nuclear protein related to the Sno/Ski family of co-repressors. We have identified Dachshund as an inhibitor of Homothorax-Yorkie-mediated cell proliferation. Loss of dachshund induces Yorkie-dependent tissue overgrowth. Conversely, overexpressing dachshund inhibits tissue growth, prevents Yorkie or Homothorax-mediated cell proliferation of disc epithelia and restricts the transcriptional activity of the Yorkie-Homothorax complex on the bantam enhancer in Drosophila cells. In addition, Dachshund collaborates with the Decapentaplegic receptor Thickveins to repress Homothorax and Cyclin B expression in quiescent precursors. The antagonistic roles of Homothorax and Dachshund in Yorkie activity, together with their mutual repression, ensure that progenitor and precursor cells are under distinct proliferation regimes. Based on the crucial role of the human dachshund homolog DACH1 in tumorigenesis, our work suggests that DACH1 might prevent cellular transformation by limiting the oncogenic activity of YAP and/or TAZ.

Pertenece a

ARCA - Access to Research and Communication Annals - IGC Repository  

Autor(es)

Bras -  Pereira, C. -  Casares, F. -  Janody, F. - 

Id.: 65894631

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveDachshund - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] info:eu-repo/grantAgreement/FCT/3599-PPCDT/71674/PT
[References] http://dev.biologists.org/content/142/8/1470

Fecha de contribución: 07-jul-2016

Contacto:

Localización:
* The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex Catarina Brás-Pereira, Fernando Casares, Florence Janody Development 2015 142: 1470-1479; doi: 10.1242/dev.113340
* 10.1242/dev.113340

Otros recursos de la mismacolección

  1. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells This deposit is composed by the main article and supplementary files of the publication.
  2. dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis Proper organ patterning depends on a tight coordination between cell proliferation and differentiati...
  3. Requirements for Mediator Complex Subunits Distinguish Three Classes of Notch Target Genes at the Drosophila Wing Margin Spatial and temporal gene regulation relies on a combinatorial code of sequence-specific transcripti...
  4. A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis E-cadherin plays a pivotal role in epithelial cell polarity, cell signalling and tumour suppression....
  5. Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway The conserved Hippo signaling pathway regulates multiple cellular events, including tissue growth, c...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.