1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have been implicated in the pathogenesis of many common human diseases. Integral to the UPR and an important determinant in cell fate is the expression of the pro-apoptotic transcription factor C/EBP homologous protein (CHOP). This is promoted by activating transcription factor 4 (ATF4) whose expression is rapidly up-regulated in response to ER stress through an eIF2α phosphorylation-dependent increase in protein synthesis. Our data demonstrates that this ER stress-induced increase in ATF4 and CHOP expression is initiated by an increase in Atf4 and Chop mRNA, which is also dependent upon eIF2α phosphorylation. Despite being dependent on eIF2α phosphorylation, we provide evidence that these increases in Atf4 and Chop mRNA expression may occur independently of de novo protein synthesis. Moreover, we show that ER stress-induced Chop mRNA expression is exacerbated by Sirtuin-1 (SIRT1) inhibition indicating that changes in the energy status of the cell may play an important role in its regulation. This work highlights and extends previous findings, and provides important new insights into the mechanism of ER stress-induced expression of Atf4 and Chop mRNA that clearly warrants further investigation.

Pertenece a

Faculty of Technology ePrints Service  


Chan, S. M. H. -  Zhao, X. -  Elfowiris, A. -  Ratnam, C. -  Herbert, T. P. - 

Id.: 70120495

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf - 

Palabras claveB200 Pharmacology, Toxicology and Pharmacy - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  application/pdf - 

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/28210/
[References] 10.1016/j.biochi.2017.04.018

Fecha de contribución: 05-may-2018


* Chan, S. M. H. and Zhao, X. and Elfowiris, A. and Ratnam, C. and Herbert, T. P. (2017) The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells. Biochimie, 138 . pp. 156-167. ISSN 0300-9084

Otros recursos del mismo autor(es)

  1. Search for a new heavy gauge-boson resonance decaying into a lepton and missing transverse momentum in 36 fb-1 of pp collisions at √s = 13 TeV with the ATLAS experiment The results of a search for new heavy W bosons decaying to an electron or muon and a neutrino using ...
  2. Search for long-lived charginos based on a disappearing-track signature in pp collisions at √s = 13 TeV with the ATLAS detector This paper presents a search for direct electroweak gaugino or gluino pair production with a chargin...
  3. Fabrication and characterization of femtosecond laser induced microstructures in chalcohalide glasses. International audience
  4. Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb−1 of √s = 13 TeV pp collision data with the ATLAS detector A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states ...
  5. Measurement of inclusive jet and dijet cross-sections in proton-proton collisions at √s = 13 TeV with the ATLAS detector Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass ...

Otros recursos de la mismacolección

  1. Bone metabolic responses to low energy availability achieved by diet or exercise in active eumenorrheic women Purpose We aimed to explore the effects of low energy availability (EA)[15 kcal·kg lean body mass (L...
  2. Model-Free Trajectory-based Policy Optimization with Monotonic Improvement Many of the recent trajectory optimization algorithms alternate between linear approximation of the ...
  3. Life satisfaction and diet in transition: Evidence from the Russian Longitudinal Monitoring Survey This paper develops a theoretical framework and provides empirical evidence on the impacts of diet a...
  4. Prospects for biocontrol of Vibrio parahaemolyticus contamination in blue mussels (Mytilus edulus) – a year-long study Vibrio parahaemolyticus is an environmental organism normally found in subtropical estuarine environ...
  5. Landscape in the Mist: thinking beyond the perimeter fence The chapter engages with the idea of the actor as agent and critical presence in the film (Landscape...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.