1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have been implicated in the pathogenesis of many common human diseases. Integral to the UPR and an important determinant in cell fate is the expression of the pro-apoptotic transcription factor C/EBP homologous protein (CHOP). This is promoted by activating transcription factor 4 (ATF4) whose expression is rapidly up-regulated in response to ER stress through an eIF2α phosphorylation-dependent increase in protein synthesis. Our data demonstrates that this ER stress-induced increase in ATF4 and CHOP expression is initiated by an increase in Atf4 and Chop mRNA, which is also dependent upon eIF2α phosphorylation. Despite being dependent on eIF2α phosphorylation, we provide evidence that these increases in Atf4 and Chop mRNA expression may occur independently of de novo protein synthesis. Moreover, we show that ER stress-induced Chop mRNA expression is exacerbated by Sirtuin-1 (SIRT1) inhibition indicating that changes in the energy status of the cell may play an important role in its regulation. This work highlights and extends previous findings, and provides important new insights into the mechanism of ER stress-induced expression of Atf4 and Chop mRNA that clearly warrants further investigation.

Pertenece a

Faculty of Technology ePrints Service  

Autor(es)

Chan, S. M. H. -  Zhao, X. -  Elfowiris, A. -  Ratnam, C. -  Herbert, T. P. - 

Id.: 70120495

Versión: 1.0

Estado: Final

Palabras claveB200 Pharmacology, Toxicology and Pharmacy - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/28210/
[References] 10.1016/j.biochi.2017.04.018

Fecha de contribución: 05-oct-2017

Contacto:

Localización:
* Chan, S. M. H. and Zhao, X. and Elfowiris, A. and Ratnam, C. and Herbert, T. P. (2017) The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells. Biochimie, 138 . pp. 156-167. ISSN 0300-9084

Otros recursos del mismo autor(es)

  1. Preliminary investigation of the microwave pyrolysis mechanism of sludge based on high frequency structure simulator simulation of the electromagnetic field distribution International audience
  2. Performance of the ATLAS track reconstruction algorithms in dense environments in LHC run 2 With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 TeV for Ru...
  3. Jet energy scale measurements and their systematic uncertainties in proton-proton collisions at √s = 13 TeV with the ATLAS detector et energy scale measurements and their systematic uncertainties are reported for jets measured with ...
  4. Evidence that Ca 2+ within the microdomain of the l-type voltage gated Ca 2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1 Glucagon like peptide-1 (GLP-1) is released from intestinal L-cells in response to nutrient ingestio...
  5. Search for new phenomena in dijet events using 37 fb−1 of pp collision data collected at s=13 TeV with the ATLAS detector Dijet events are studied in the proton-proton collision data set recorded at √ s = 13     TeV with...

Otros recursos de la mismacolección

  1. Evidence of auditory insensitivity to vocalization frequencies in two frogs The emergence and maintenance of animal communication systems requires the co-evolution of signal an...
  2. Dog bites: a multidisciplinary perspective .
  3. Architectural and historical impact assessment for the house and associated outbuildings known as Kingthorpe, Umlaas Road district, KwaZulu-Natal This report was commissioned to establish the impact of the demolition of a early 20th century fibre...
  4. Historical and architectural impact assessment report for the Port Durnford State Forest, Umhlatuze, Uthungulu District Municipality This is an architectural and heritage impact assessment for structures found on the Port Durnford Es...
  5. Architectural and archaeological impact assessment for the property known as The Secret Garden, on the Remainder of Portion 1 of the Farm Cluny Park no 14809, Msunduzi Municipality This is a heritage impact assessment with respect to alterations and additions carried out to an old...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.