Tuesday, September 2, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene, cause atrioventricular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardial cushion development. These GATA4 missense mutations, but not a mutation causing secundum atrial septal defects (S52F), demonstrated impaired protein interactions with SMAD4, a transcription factor required for canonical bone morphogenetic protein/transforming growth factor-β (BMP/TGF-β) signaling. Gata4 and Smad4 genetically interact in vivo: atrioventricular septal defects result from endothelial-specific Gata4 and Smad4 compound haploinsufficiency. Endothelial-specific knockout of Smad4 caused an absence of valve-forming activity: Smad4-deficient endocardium was associated with acellular endocardial cushions, absent epithelial-to-mesenchymal transformation, reduced endocardial proliferation, and loss of Id2 expression in valve-forming regions. We show that Gata4 and Smad4 cooperatively activated the Id2 promoter, that human GATA4 mutations abrogated this activity, and that Id2 deficiency in mice could cause atrioventricular septal defects. We suggest that one determinant of the phenotypic spectrum caused by human GATA4 mutations is differential effects on GATA4/SMAD4 interactions required for endocardial cushion development.

Autor(es): Moskowitz, Ivan P. -  Wang, Jun -  Peterson, Michael A. -  Pu, William T. -  Mackinnon, Alexander C. -  Oxburgh, Leif -  Chu, Gerald C. -  Sarkar, Molly -  Berul, Charles -  Smoot, Leslie -  Robertson, Elizabeth J. -  Schwartz, Robert -  Seidman, Jonathan G. -  Seidman, Christine E. - 

Id.: 54459972

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveBiological Sciences - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 09-sep-2011

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. Influenza H7N9 and H9N2 Viruses: Coexistence in Poultry Linked to Human H7N9 Infection and Genome Characteristics Avian influenza virus A of the novel H7N9 reassortant subtype was recently found to cause severe hum...
  2. Independent Optical Excitation of Distinct Neural Populations Optogenetic tools enable the causal examination of how specific cell types contribute to brain circu...
  3. TNF, Acting through Inducibly Expressed TNFR2, Drives Activation and Cell Cycle Entry of c-kit+ Cardiac Stem Cells in Ischemic Heart Disease TNF, signaling through TNFR2, has been implicated in tissue repair, a process that in the heart may ...
  4. The mysterious origins of coronary vessels The origin of the coronary vessels remains a mystery. Here we discuss recent studies that address th...
  5. Retention in methadone and buprenorphine treatment among African Americans Methadone has been the most commonly used pharmacotherapy for the treatment of opioid dependence in ...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso