Sunday, October 26, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene, cause atrioventricular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardial cushion development. These GATA4 missense mutations, but not a mutation causing secundum atrial septal defects (S52F), demonstrated impaired protein interactions with SMAD4, a transcription factor required for canonical bone morphogenetic protein/transforming growth factor-β (BMP/TGF-β) signaling. Gata4 and Smad4 genetically interact in vivo: atrioventricular septal defects result from endothelial-specific Gata4 and Smad4 compound haploinsufficiency. Endothelial-specific knockout of Smad4 caused an absence of valve-forming activity: Smad4-deficient endocardium was associated with acellular endocardial cushions, absent epithelial-to-mesenchymal transformation, reduced endocardial proliferation, and loss of Id2 expression in valve-forming regions. We show that Gata4 and Smad4 cooperatively activated the Id2 promoter, that human GATA4 mutations abrogated this activity, and that Id2 deficiency in mice could cause atrioventricular septal defects. We suggest that one determinant of the phenotypic spectrum caused by human GATA4 mutations is differential effects on GATA4/SMAD4 interactions required for endocardial cushion development.

Autor(es): Moskowitz, Ivan P. -  Wang, Jun -  Peterson, Michael A. -  Pu, William T. -  Mackinnon, Alexander C. -  Oxburgh, Leif -  Chu, Gerald C. -  Sarkar, Molly -  Berul, Charles -  Smoot, Leslie -  Robertson, Elizabeth J. -  Schwartz, Robert -  Seidman, Jonathan G. -  Seidman, Christine E. - 

Id.: 54459972

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveBiological Sciences - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 09-sep-2011

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. Broad-band semiconductor optical amplifiers Broad-band semiconductor optical amplifiers (SOAs) with different thicknesses and thin bulk tensile-...
  2. Yiyang san xian yi ji. Title from case.
  3. Modeling Studies of Atmospheric Pressure Microplasmas: Plasma Dynamics, Surface Interaction and Applications. Technologies based on atmospheric-pressure microplasmas (APMs) have been widely developed due to the...
  4. The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes
  5. Nonlinear Behaviors of Tail Dependence and Cross-Correlation of Financial Time Series Model Nonlinear behaviors of tail dependence and cross-correlation of financial time series are reproduced...

Otros recursos de la misma colección

  1. Correction for In This Issue
  2. Continuity of mammalian fauna over the last 200,000 y in the Indian subcontinent Mammalian extinction during the past several hundred thousand years has been a major focus for evolu...
  3. Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles This study provides the first evidence to our knowledge that the effects of alcohol on social bondin...
  4. Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense Candida albicans is the most prevalent human fungal pathogen. To combat the host immune response, C....
  5. Massive programmed translational jumping in mitochondria During translation, ribosomes decode mRNAs in a sequential fashion. In this paper, we report the dis...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso