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Context: Besides their potential action in the treatment of type 2 diabetes mellitus (T2DM), GLP-1 analogues have been shown to decrease satiety and food intake. However, little is known about their effects on food hedonic and taste perceptions. Objective: The objective of the study was to investigate the impact of GLP-1 analogue Liraglutide on the liking and wanting component of the food reward system as well as on taste sensitivity in T2DM patients. Research design and methods: Thirty T2DM patients were studied before and after 3 months of daily Liraglutide treatment (1.2 mg). In each trial, blood samples were collected and body mass composition was analyzed by dual-energy X-ray absorptiometry. Liking, recalled liking and wanting for lipids, proteins and carbohydrates were assessed and detection thresholds for salt, sweet and bitter tastes were measured. Results: After three months of daily treatment with Liraglutide, T2DM patients had a significant decrease in hunger sensation (p<0.01), food intake (p<0.01) and weight (p<0.01) but not in the pleasure in eating. A reduction in plasma leptin (p<0.01) and ghrelin (p<0.01) levels was also observed. Liking (p=0.04), recalled liking (p=0.05) and wanting (p<0.01) for fatty foods were lowered by the treatment. Sensitivity to sweet taste was improved (p=0.04) whereas it remained unchanged for salty and bitter tastes. Conclusions: This is the first study to show a decrease in hedonic response for fatty foods and an increase in sweet taste sensitivity induced by GLP-1 analogues. These results are of interest in the understanding of weight loss mechanisms and cardiovascular risk improvement induced by GLP-1 analogues.

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Autor(es)

Meillon , S. -  Brindisi , M -  C. -  Vergès , B. -  Deglaire , Amélie -  Brondel , L. -  Penicaud , L. - 

Id.: 70743673

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras clavePHARMACOLOGY & PHARMACY - 

Tipo de recurso: info:eu-repo/semantics/article  -  Journal articles  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] ISSN: 0767-3981
[IsBasedOn] EISSN: 1472-8206
[IsBasedOn] Fundamental and Clinical Pharmacology
[IsBasedOn] https://hal-agrocampus-ouest.archives-ouvertes.fr/hal-00849252
[IsBasedOn] Fundamental and Clinical Pharmacology, Wiley, 2012, 26 (SI 1), pp.28-28

Fecha de contribución: 22-mar-2018

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