1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

The Kv2.1 channel generates a delayed-rectifier current in neurons and is responsible for modulation of neuronal spike frequency and membrane repolarization in pancreatic β-cells and cardiomyocytes. As with other tetrameric voltage-activated K+-channels, it has been proposed that each of the four Kv2.1 voltage-sensing domains activates independently upon depolarization, leading to a final concerted transition that causes channel opening. The mechanism by which voltage-sensor activation is coupled to the gating of the pore is still not understood. Here we show that the carbon-monoxide releasing molecule 2 (CORM-2) is an allosteric inhibitor of the Kv2.1 channel and that its inhibitory properties derive from the CORM-2 ability to largely reduce the voltage dependence of the opening transition, uncoupling voltage-sensor activation from the concerted opening transition. We additionally demonstrate that CORM-2 modulates Shaker K+-channels in a similar manner. Our data suggest that the mechanism of inhibition by CORM-2 may be common to voltage-activated channels and that this compound should be a useful tool for understanding the mechanisms of electromechanical coupling.

Pertenece a

PubMed Central (PMC3 - NLM DTD)  

Autor(es)

Jara -  Oseguera, Andrés -  Ishida, Itzel G. -  Rangel -  Yescas, Gisela E. -  Espinosa -  Jalapa, Noel -  Pérez -  Guzmán, José A. -  Elías -  Viñas, David -  Le Lagadec, Ronan -  Rosenbaum, Tamara -  Islas, León D. - 

Id.: 55281516

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras claveMembrane Biology - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 07-may-2012

Contacto:

Localización:

Otros recursos del mismo autor(es)

  1. 1 pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence
  2. $rec.titulo Geometric reconstruction and trishear model of folding: a case study in the western Principal Cordil...
  3. A COMPUTATIONAL STUDY OF CO2, N2, AND CH4 ADSORPTION IN ZEOLITES The adsorption properties of CO2, N2 and CH4 in all-silica zeolites were studied using molecular sim...
  4. Elevated GH/IGF-I promotes mammary tumors in high-fat doi:10.1093/carcin/bgu161
  5. of the quorum-sensor NprR dependent conformational changes regulate the transcriptional activity

Otros recursos de la misma colección

  1. Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54*♦ Filamentous plant pathogens deliver effector proteins to host cells to promote infection. The Phytop...
  2. Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury* Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can reorganize/stabili...
  3. Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes* Enzymes that utilize the cofactor pyridoxal 5′-phosphate play essential roles in amino acid metaboli...
  4. Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases* Background: The highly related small GTPases RalA and RalB exhibit distinct functions in cancer cell...
  5. The MLLE Domain of the Ubiquitin Ligase UBR5 Binds to Its Catalytic Domain to Regulate Substrate Binding* Background: Paip2 and GW182 are translation effectors that interact with the E3 ubiquitin ligase UBR...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.