Thursday, November 27, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Uncoupling Charge Movement from Channel Opening in Voltage-gated Potassium Channels by Ruthenium Complexes*

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: The Kv2.1 channel generates a delayed-rectifier current in neurons and is responsible for modulation of neuronal spike frequency and membrane repolarization in pancreatic β-cells and cardiomyocytes. As with other tetrameric voltage-activated K+-channels, it has been proposed that each of the four Kv2.1 voltage-sensing domains activates independently upon depolarization, leading to a final concerted transition that causes channel opening. The mechanism by which voltage-sensor activation is coupled to the gating of the pore is still not understood. Here we show that the carbon-monoxide releasing molecule 2 (CORM-2) is an allosteric inhibitor of the Kv2.1 channel and that its inhibitory properties derive from the CORM-2 ability to largely reduce the voltage dependence of the opening transition, uncoupling voltage-sensor activation from the concerted opening transition. We additionally demonstrate that CORM-2 modulates Shaker K+-channels in a similar manner. Our data suggest that the mechanism of inhibition by CORM-2 may be common to voltage-activated channels and that this compound should be a useful tool for understanding the mechanisms of electromechanical coupling.

Autor(es): Jara -  Oseguera, Andrés -  Ishida, Itzel G. -  Rangel -  Yescas, Gisela E. -  Espinosa -  Jalapa, Noel -  Pérez -  Guzmán, José A. -  Elías -  Viñas, David -  Le Lagadec, Ronan -  Rosenbaum, Tamara -  Islas, León D. - 

Id.: 55281516

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveMembrane Biology - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 07-may-2012

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. Stand-alone memory controller for graphics system There has been a dramatic increase in the complexity of graphics applications in System-on-Chip (SoC...
  2. Human/non-human: Gender dynamics and the female/animal condition in medieval culture
  3. Correspondence: Long-term stability of surgical-orthodontic correction of class III malocclusions with long-face syn...
  4. The Metamorphosis of Narcissus: Communal Activation Promotes Relationship Commitment Among Narcissists The online version of this article can be found at:
  5. The cientificWorldJOURNAL Research Article Morphostructural Characterization of Rice Grain (Oryza sativa L.) Variety Morelos A-98 during Filling Stages Copyright © 2012 Rosa Elena Espinosa-Mendoza et al. This is an open access article distributed under...

Otros recursos de la misma colección

  1. TROY Interacts with Rho Guanine Nucleotide Dissociation Inhibitor α (RhoGDIα) to Mediate Nogo-induced Inhibition of Neurite Outgrowth* Background: TROY, together with the Nogo receptor, mediates Nogo-66 induced neurite outgrowth inhibi...
  2. Direct Inhibition of Gcn5 Protein Catalytic Activity by Polyglutamine-expanded Ataxin-7* Background: Polyglutamine expansion of the ataxin-7 protein, a subunit of the SAGA (Spt-Ada-Gcn5-ace...
  3. Hydrolysis at One of the Two Nucleotide-binding Sites Drives the Dissociation of ATP-binding Cassette Nucleotide-binding Domain Dimers* Background: Nucleotide-binding domains (NBDs) of ABC proteins bind two ATPs, but it is unknown wheth...
  4. Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction* Background: Na/K-ATPase signaling regulates sodium reabsorption in renal proximal tubules.
  5. RhoG Protein Regulates Glycoprotein VI-Fc Receptor γ-Chain Complex-mediated Platelet Activation and Thrombus Formation* Background: RhoG is a ubiquitously expressed member of the Rho family of GTPases.

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso