1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso

Descripción

Our intention is to find similarity among the time series expressions of the genes in microarray experiments. It is hypothesized that at a given time point the concentration of one gene’s mRNA is directly affected by the concentration of other gene’s mRNA, and may have biological significance. We define dissimilarity between two time-series data set as the variance of Euclidean distances of each time points. The large numbers of gene expressions make the calculation of variance of distance in each point computationally expensive and therefore computationally challenging in terms of execution time. For this reason we use autoregressive model which estimates nineteen points gene expression to a three point vector. It allows us to find variance of difference between two data sets without point-to-point matching. Previous analysis from the microarray experiments data found that 62 genes are regulated following EGF (Epidermal Growth Factor) and HRG (Heregulin) treatment of the MCF-7 breast cancer cells. We have chosen these suspected cancer-related genes as our reference and investigated which additional set of genes has similar time point expression profiles. Keeping variance of difference as a measure of distance, we have used several methods for clustering the gene expression data, such as our own maximum clique finding heuristics and hierarchical clustering. The results obtained were validated through a text mining study. New predictions from our study could be a basis for further investigations in the genesis of breast cancer. Overall in 84 new genes are found in which 57 genes are related to cancer among them 35 genes are associated with breast cancer.

Pertenece a

ETD at Indian Institute of Science  

Autor(es)

Mukhopadhyay, Sayan - 

Id.: 70843335

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveMicroarray Data Clustering - 

Tipo de recurso: Thesis  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] G26721

Fecha de contribución: 10-ene-2018

Contacto:

Localización:

Otros recursos que te pueden interesar

  1. Experimental and theoretical insights in the alkene–arene intramolecular π-stacking interaction Chiral acrylic esters derived from biomass were developed as models to have a better insight in the ...
  2. First record of Chaetophractus villosus (Mammalia, Dasypodidae) in the late Pleistocene of Corrientes Province (Argentina) Chaetophractus villosus is recorded from the Chapadmalalian (middle Pliocene) to present. This speci...
  3. Problematizações sobre políticas da arte na licenciatura em artes visuais : é preciso gostar da arte de outro jeito, a licenciatura é uma praça A tese apresenta a problematização de políticas da arte na licenciatura em artes visuais indagando s...
  4. Como decide o Supremo Tribunal Federal quanto à interferência em cargos políticos quando inexiste previsão constitucional expressa : estudo de casos (2015-2017) Na legislatura atual (2015-2018), o Supremo Tribunal Federal tem estado cada vez mais presente nos r...
  5. O direito à moradia e o direito ao meio ambiente em colisão : uma análise da previsão normativa de regularização fundiária urbana em áreas de preservação permanente (APPs) O presente trabalho tem como escopo principal analisar a imbricada e conflituosa relação entre os di...

Otros recursos de la mismacolección

  1. Communication Structure and Mixing Patterns in Complex Networks Real world systems like biological, social, technological, infrastructural and many others can be mo...
  2. Stochastic Chemical Kinetics : A Study on hTREK1 Potassium Channel Chemical reactions involving small number of reacting molecules are noisy processes. They are simula...
  3. Analysis of Molecular Dynamics Trajectories of Proteins Performed using Different Forcefields and Identifiction of Mobile Segments The selection of the forcefield is a crucial issue in any MD related work and there is no clear indi...
  4. Polymorphic ASIC : For Video Decoding Video applications are becoming ubiquitous in recent times due to an explosion in the number of devi...
  5. Automated Selection of Hyper-Parameters in Diffuse Optical Tomographic Image Reconstruction Diffuse optical tomography is a promising imaging modality that provides functional information of t...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.