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The KnowledgeBank at OSU (75.894 recursos)

Knowledge Bank contains collections of presentations, publications and reports related to Ohio State University.

21st Hayes Graduate Research Forum (April, 2007)

Mostrando recursos 1 - 8 de 8

  1. GM-CSF Inhibits Breast Cancer Growth and Metastases in Mice and Induces Hypoxia in the Tumor Proper

    Roberts, Ryan
    Background: Scientists have begun to appreciate the important role that normal body tissues play in cancer development and progression. Recent studies demonstrate that cancer cells can trick blood vessels and other cells into helping tumors grow and spread. In 2001, Lin, et al, showed that mice unable to produce M-CSF (a growth factor which stimulates a certain type of immune cell called a macrophage) can still get breast tumors, but these tumors don't spread. We later proved that those findings could be explained, at least in part, by the fact that M-CSF makes macrophages produce and secrete VEGF, a powerful...

  2. A Case study: Comparing reading strategies of advanced CFL learners on different genres and media of text

    Kang, Hana
    Despite the increasing number of advanced Chinese as a Foreign Language (CFL) learners in American universities, there have been very few investigations of their reading processes and strategies. Most researchers have examined learners’ Chinese character recognition (e.g., Hayes, 1987; Wen, 1995), with the notable exception of Ke’s (1997) study on CFL learners’ approaches to reading. However, Ke (1997) limited the study to one genre of paper-based text (i.e., newspapers) in order to explore the reading processes and strategies of CFL learners. Currently, though, CFL learners engage in various kinds of screen-based hypertext reading, even in the early stages of Chinese...

  3. Observations of Wave-induced Vortices over Ripples

    Nichols, Claire
    Engineering: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)

  4. Searching for Physics Beyond the Standard Model with a Rare Decay

    Corwin, Luke
    Mathematical and Physical Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)

  5. Regulation of Invasiveness of Glioblastoma Multiforme Cell Lines and Tumor Stem Cells by Sphingosine Kinase and Sphingosine 1-Phosphate Reveals Potential Molecular Therapeutic Targets

    Young, Nicholas
    Poster: 3rd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)

  6. Interactions of unsaturated fat or coconut oil with Rumensin® on milk fat production might be mediated through inhibition of specific protozoal genera

    Reveneau, Carine
    Polyunsaturated fatty acids (PUFA) feeding often decreases protozoal numbers in the rumen. Animal-vegetable fat (AV), a by-product of the food industry, is readily available to provide PUFA in dairy diets. However, the response to AV supplementation on protozoal numbers is not consistent, possibly due to biohydrogenation (BH) of PUFA in the rumen. Long chain saturated FA are less toxic to protozoa; therefore, the BH of PUFA removes their potential inhibitory effects. In contrast, evidence from OSU supports the contention that protozoa are a vehicle for passage of PUFA or other intermediates of BH that do not promote MFD. AV supplementation in combination with Rumensin® (R), an ionophore improving feed...

  7. Tropomyosin 4 Regulates Osteoclast Function through Actin Adhesion Structures

    McMichael, Brooke
    Osteoclasts, large, multinucleated cells which resorb bone, function to maintain bone degradation vital for maintenance and repair of bone tissue. Osteoclasts function by forming unique actin structures for migration, podosomes, and bone resorption, actin rings. The actin cytoskeleton also transports V-ATPases to the plasma membrane. Thus regulation of actin is central to the understanding osteoclast function. Tropomyosins are proteins that bind to actin and regulate other proteins association with actin. The purpose of this study is to investigate the role of tropomyosins, specifically tropomyosin 4, in osteoclasts. Our research initially demonstrated the presence of eight tropomyosins in osteoclasts. Confocal imaging demonstrated...

  8. Elucidating the Role of Macrophages in Visceral Leishmaniasis

    Snider, Heidi
    Background: Leishmaniasis is a tropical disease caused by protozoan parasite species belonging to the genus Leishmania. Depending on the infective species, leishmaniasis can manifest as one of three major disease states – cutaneous, mucocutaneous or visceral. L. donovani causes visceral disease with tropism for reticuloendothelial organs. Left untreated, L. donovani infections are fatal, often due to secondary bacterial infections and complications resulting from profound hepatosplenomegaly. Leishmania species parasitize host cell macrophages, the cell type that is ultimately responsible for killing parasites under correct immune conditions. Experimental mouse models that mount type I CD4+ T cell (TH1) responses are capable of...

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