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Archivo Digital UPM (76,942 recursos)
This is an institutional repository providing access to the research output of the institution. Primarily contains thesis.

Materia = Medicina

Mostrando recursos 1 - 20 de 503

1. Herramienta basada en vistas para la generación automática de anotaciones de fuentes RDF - Lloret Carbonell, Andoni
Durante los últimos años, el imparable crecimiento de fuentes de datos biomédicas, propiciado por el desarrollo de técnicas de generación de datos masivos (principalmente en el campo de la genómica) y la expansión de tecnologías para la comunicación y compartición de información ha propiciado que la investigación biomédica haya pasado a basarse de forma casi exclusiva en el análisis distribuido de información y en la búsqueda de relaciones entre diferentes fuentes de datos. Esto resulta una tarea compleja debido a la heterogeneidad entre las fuentes de datos empleadas (ya sea por el uso de diferentes formatos, tecnologías, o modelizaciones de...

2. Implementación del modelo RIM de HL7 v3 en orientación a objetos y su uso en procesos de interoperabilidad semántica - Alonso Oset, Enrique
El trabajo ha sido realizado dentro del marco de los proyectos EURECA (Enabling information re-Use by linking clinical REsearch and Care) e INTEGRATE (Integrative Cancer Research Through Innovative Biomedical Infrastructures), en los que colabora el Grupo de Informática Biomédica de la UPM junto a otras universidades e instituciones sanitarias europeas. En ambos proyectos se desarrollan servicios e infraestructuras con el objetivo principal de almacenar información clínica, procedente de fuentes diversas (como por ejemplo de historiales clínicos electrónicos de hospitales, de ensayos clínicos o artículos de investigación biomédica), de una forma común y fácilmente accesible y consultable para facilitar al máximo...

3. Enhancing iDynoMiCS framework with a plasmid conjugation module - Arroyo García, Aurora Sofía
Actualmente existen aplicaciones que permiten simular el comportamiento de bacterias en distintos hábitats y los procesos que ocurren en estos para facilitar su estudio y experimentación sin la necesidad de un laboratorio. Una de las aplicaciones de software libre para la simulación de poblaciones bacteriológicas mas usada es iDynoMiCS (individual-based Dynamics of Microbial Communities Simulator), un simulador basado en agentes que permite trabajar con varios modelos computacionales de bacterias en 2D y 3D. Este simulador permite una gran libertad al configurar una numerosa cantidad de variables con respecto al entorno, reacciones químicas y otros detalles importantes. Una característica importante es el...

4. Integration of wearable devices in a wireless sensor network for an e-health application - Castillejo Parrilla, Pedro; Martínez Ortega, José Fernán; Rodríguez Molina, Jesús; Cuerva García, Alexandra
Applications based on Wireless Sensor Networks for Internet of Things scenarios are on the rise. The multiple possibilities they offer have spread towards previously hard to imagine fields, like e-health or human physiological monitoring. An application has been developed for its usage in scenarios where data collection is applied to smart spaces, aiming at its usage in fire fighting and sports. This application has been tested in a gymnasium with real, non-simulated nodes and devices. A Graphic User Interface has been implemented to suggest a series of exercises to improve a sportsman/woman s condition, depending on the context and their profile....

5. Knowledge-based spatiotemporal linear abstraction - Shahar, Yuval; Molina, Martin
We present a theoretical framework and a case study for reusing the same conceptual and computational methodology for both temporal abstraction and linear (unidimensional) space abstraction, in a domain (evaluation of traffic-control actions) significantly different from the one (clinical medicine) in which the method was originally used. The method, known as knowledge-based temporal abstraction, abstracts high-level concepts and patterns from time-stamped raw data using a formal theory of domain-specific temporal-abstraction knowledge. We applied this method, originally used to interpret time-oriented clinical data, to the domain of traffic control, in which the monitoring task requires linear pattern matching along both space and...

6. Intelligent Therapy Assistant (ITA) for cognitive rehabilitation in patients with Acquired Brain Injury - Solana Sánchez, Javier; Cáceres Taladriz, César; García Molina, A.; Chausa Fernández, Paloma; Opisso, Eloy; Roig Rovira, Teresa; Menasalvas Ruiz, Ernestina; Tormos Muñoz, José M.; Gómez Aguilera, Enrique J.
This paper presents the design, development and first evaluation of an algorithm, named Intelligent Therapy Assistant (ITA), which automatically selects, configures and schedules rehabilitation tasks for patients with cognitive impairments after an episode of Acquired Brain Injury. The ITA is integrated in "Guttmann, Neuro Personal Trainer" (GNPT), a cognitive tele-rehabilitation platform that provides neuropsychological services.

7. Registration and fusion of contrast-enhanced MRI myocardial substrate maps and X-ray angiograms - Ortuño Fisac, Juan Enrique; Pérez David, Esther; Arenal Maíz, Ángel; Bermejo, Javier; Santos Lleo, Andres de; Ledesma Carbayo, María Jesús
The aim of this work is to provide the necessary methods to register and fuse the endo-epicardial signal intensity (SI) maps extracted from contrast-enhanced magnetic resonance imaging (ceMRI) with X-ray coronary ngiograms using an intrinsic registrationbased algorithm to help pre-planning and guidance of catheterization procedures. Fusion of angiograms with SI maps was treated as a 2D-3D pose estimation, where each image point is projected to a Plücker line, and the screw representation for rigid motions is minimized using a gradient descent method. The resultant transformation is applied to the SI map that is then projected and fused on each angiogram....

8. Utilidad de los mapas de intensidad de señal basados en secuencias de realce tardía 3D para caracterizar el sustrato arritmogénico en pacientes con taquicardía ventricular isquémica - Pérez David, Esther; Ledesma Carbayo, María Jesús; Ortuño Fisac, Juan Enrique; Ávila Alonso, Pablo; Barrio Lucía, Alicia; Arenal Maíz, Ángel; Bermejo Thomas, Javier; Fernández Avilés, Francisco
La escara miocárdica constituye el sustrato arritmogénico de los pacientes con TV isquémica. Los mapas de intensidad de señal (IS) obtenidos a partir de mágenes de realce tardío (RT) pueden ser una alternativa no invasiva a los mapas electroanatómicos para estudiar la arquitectura de la escara. El objetivo de este trabajo es describir las características de las escaras observadas en los pacientes (p) con TV isquémicas.

9. Diferencias en el sustrato endo y epicárdico de las taquicardias ventriculares posinfarto analizado mediante resonancia magnética cardiaca con realce tardío - Ávila Alonso, Pablo; Arenal Maíz, Ángel; Pérez David, Esther; Fernández Portales, Javier; Crisóstomo, Verónica; Ledesma Carbayo, María Jesús; Bermejo Thomas, Javier; Fernández Avilés, Francisco
Algunas taquicardias ventriculares (TV) posinfarto se localizan en el epicardio. La identificación de diferencias en el sustrato de las TV endocárdicas y epicárdicas permitiría definir una mejor estrategia de ablación.

10. Magnetic resonance imaging based signal intensity mapping predicts appropriate therapies after prophylactic ventricular tachycardia substrate ablation in patients with previous myocardial infarction and secondary prevention implantable cardioverter-defibrillator implantation - Bravo, Loreto; Arenal Maíz, Ángel; Pérez David, Esther; Ávila Alonso, Pablo; Rojas, Antonio; Atienza, Felipe; González Torrecilla, Esteban; Datino, Tomás; Ledesma Carbayo, María Jesús; Loughlin, Gerard; Bermejo, Javier; Fernández Avilés, Francisco
The aim of this study was to determine the capability of ceMRI based signal intensity (SI) mapping to predict appropriate ICD therapies after PVTSA.

11. La energía disipada en membranas de pericardio sometidas a fatiga uniaxial como predictor de su durabilidad. - Tobaruela, A.; Rojo Pérez, Francisco Javier; Guinea Tortuero, Gustavo V.
El pericardio es un material que se utiliza cuando se hace necesaria la sustitución de los velos de las válvulas cardiacas. En el presente trabajo se evalúa la durabilidad en fatiga de membranas de pericardio de ternera tratadas con glutaraldehído. Con tal propósito, se ensayaron 72 probetas de pericardio en condiciones fisiológicas de humedad y temperatura. Los ensayos se realizaron primero a fatiga hasta un número determinado de ciclos, entre un mínimo de 100 y un máximo de 4000, para luego ensayarse hasta rotura mediante un ensayo uniaxial de tracción simple. Las probetas consideradas control se sometieron a un único...

12. Estudio anatómico-funcional del pie - Rivas Quesada, Juan A.
El estudio del pie, de su funcionamiento, de su estructuración, de sus arcos, de todo aquello que lo hace tan maravillosamente funcional, ha sido para mí una constante atracción desde que empecé los estudios en este Instituto. Mis conocimientos de anatomía adquiridos en los primeros años de carrera, el gusto personal hacia esta materia penetrante y casi agresiva, la importancia que tiene en la formación del profesor de Educación Física, el conocimiento de la funcionalidad de las diferentes partes del cuerpo humano, la importancia que en sí mismo tiene el pie, no ya en los deportes y actividades físicas , sino...

13. GMM-based classifiers for the automatic detection of obstructive sleep apnea - Gómez García, J.A.; Blanco Murillo, José Luis; Godino Llorente, Juan Ignacio; Hernández Gómez, Luis Alfonso; Castellanos Domínguez, César Germán
The aim of automatic pathological voice detection systems is to serve as tools, to medical specialists, for a more objective, less invasive and improved diagnosis of diseases. In this respect, the gold standard for those system include the usage of a optimized representation of the spectral envelope, either based on cepstral coefficients from the mel-scaled Fourier spectral envelope (Mel-Frequency Cepstral Coefficients) or from an all-pole estimation (Linear Prediction Coding Cepstral Coefficients) forcharacterization, and Gaussian Mixture Models for posterior classification. However, the study of recently proposed GMM-based classifiers as well as Nuisance mitigation techniques, such as those employed in speaker recognition,...

14. Minimally invasive surgical video analysis: a powerful tool for surgical training and navigation - Sánchez González, Patricia; Oropesa García, Ignacio; Gómez Aguilera, Enrique J.
Analysis of minimally invasive surgical videos is a powerful tool to drive new solutions for achieving reproducible training programs, objective and transparent assessment systems and navigation tools to assist surgeons and improve patient safety. This paper presents how video analysis contributes to the development of new cognitive and motor training and assessment programs as well as new paradigms for image-guided surgery.

15. Noninvasive monitoring of serial changes in pulmonary vascular resistance and acute vasodilator testing using cardiac magnetic resonance - García Álvarez, Ana; Fernández Friera, Leticia; García Ruiz, José Manuel; Nuño Ayala, Mario; Pereda, Daniel; Fernández Jiménez, Rodigo; Guzmán, Gabriela; Sánchez Quintana, Damian; Alberich Bayarri, Ángel; Pastor Escuredo, David; Sanz Rosa, David; García Prieto, Jaime; González Mirelis, Jesús G.; Pizarro, Gonzalo; Jiménez Borreguero, Luis Jesús; Fuster, Valentín; Sanz, Javier; Ibañez, Borja
Objectives The study sought to evaluate the ability of cardiac magnetic resonance (CMR) to monitor acute and long-term changes in pulmonary vascular resistance (PVR) noninvasively. Background PVR monitoring during the follow-up of patients with pulmonary hypertension (PH) and the response to vasodilator testing require invasive right heart catheterization. Methods An experimental study in pigs was designed to evaluate the ability of CMR to monitor: 1) an acute increase in PVR generated by acute pulmonary embolization (n = 10); 2) serial changes in PVR in chronic PH (n = 22); and 3) changes in PVR during vasodilator testing in chronic PH (n = 10). CMR studies...

16. 3D Frangi-based lung vessel enhancement filter penalizing airways - Jimenez Carretero, Daniel; Santos Lleo, Andres de; Kerkstra, Sjoerd; Dewi Rudyanto, Rina; Ledesma Carbayo, María Jesús
This paper describes a fully automatic simultaneous lung vessel and airway enhancement filter. The approach consists of a Frangi-based multiscale vessel enhancement filtering specifically designed for lung vessel and airway detection, where arteries and veins have high contrast with respect to the lung parenchyma, and airway walls are hollow tubular structures with a non negative response using the classical Frangi's filter. The features extracted from the Hessian matrix are used to detect centerlines and approximate walls of airways, decreasing the filter response in those areas by applying a penalty function to the vesselness measure. We validate the segmentation method in...

17. MIA - a free and open source software for gray scale medical image analysis - Wöllny, Gert; Kellman, Peter; Ledesma Carbayo, María Jesús; Skinner, Matthew M.; Hublin, Jean-Jaques; Hierl, Thomas
Background Gray scale images make the bulk of data in bio-medical image analysis, and hence, the main focus of many image processing tasks lies in the processing of these monochrome images. With ever improving acquisition devices, spatial and temporal image resolution increases, and data sets become very large. Various image processing frameworks exists that make the development of new algorithms easy by using high level programming languages or visual programming. These frameworks are also accessable to researchers that have no background or little in software development because they take care of otherwise complex tasks. Specifically, the management of working memory is taken...

18. Anatomo-functional organization in brain networks - Pineda Pardo, José Ángel; Martínez, K.; Solana Sánchez, Ana Beatriz; Molina, Elena; Colom, Roberto; Buldú, J.M.; Hernández Tamames, J.A.; Pozo Guerrero, Francisco del
There are several studies focused on comparing rsFC networks with their structural substrate \cite{hagmann2008, honey2010}. However an accurate description of how anatomo-­functional connections are organized, both at physical and topological levels, is still to be defined. Here we present an approach to quantify the anatomo-functional organization and discuss its consistency.

19. New diagnostic and therapeutic approaches to treat ventricular tachycardias originating at the summit of the left ventricle role of merged hemodynamic-MRI and alternative ablation sources - Atienza, Felipe; Arenal Maíz, Ángel; Pérez David, Esther; Elízaga, Jaime; Ortuño Fisac, Juan Enrique; Ledesma Carbayo, María Jesús; Sánchez Quintana, Damian; Fernández Avilés, Francisco
The left ventricular (LV) summit is the most common site of idiopathic epicardial LV arrhythmias and frequently represents a diagnostic and a therapeutic challenge.1 We present a case of sustained monomorphic ventricular tachycardia (SMVT) originating at the LV summit that underwent failed cryosurgical epicardial ablation and was successfully treated with the aid of merged hemodynamic and contrast-enhanced MRI (CE-MRI).

20. Vocal tract settings in speakers suffering from obstructive sleep apnea síndrome - Blanco Murillo, José Luis; Schoentgen, Jean
Automatic systems based on speech signal analysis for the early dete ction of obstructive sleep apnea (OSA) have achieved fairly high performance rates in recent years. However, a satisfactory explanation of these results has not been available. This presentation aims at explaining via an examination of the long-term spectra of OSA patients and normal control speakers these systems’ ability to discover OSA speakers on the base of all-purpose cepstral coefficients. An in terpretation of the long- term spectra in terms of the underlying tract settings suggests that the speech of OSA patients is characterized by a pharyngeal narrowing that may be captured by acoustic...

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